Abstract

Linear IgA bullous dermatosis (LABD) is a rare auto-immune bullous disease occurring in adults or childhood. There are similarities and differences between these two subtypes of the disease. We report a twenty-seven-year-old patient with adult subtype of LABD. The disease started from the second month of gestation and remitted after the delivery. We briefly reviewed literature about the features on epidemiological and clinical data, laboratory investigations for adult linear IgA disease and childhood IgA disease. Lesions in children are mainly localized to the lower abdomen and the perineal area but in adults, face and trunk are frequently affected. The disease may be either idiopathic or triggered by several medications and some other autoimmune diseases. Direct immunofluorescence in both forms of LABD shows linear IgA deposition on the basement membrane zone. T cells and other celluar immune components are involved in the IgA-mediated autoimmune disease.

Authors and Affiliations