Research advances in the pathogenesis of metabolic associated fatty liver disease
Journal Title: Journal of Clinical Hepatology - Year 2024, Vol 40, Issue 10
Abstract
Metabolic associated fatty liver disease （MAFLD） is currently the most common liver disease around the world. MAFLD may easily progress to the adverse outcomes such as hepatitis， liver fibrosis， and liver cirrhosis， and it is often accompanied by comorbidities such as diabetes， hypertension， hyperlipidemia， hyperuricemia， and cardiovascular and cerebrovascular diseases. Etiological treatment is the cornerstone of MAFLD treatment， and due to the complexity and adverse outcome of MAFLD， it is of great significance to explore the pathogenesis of MAFLD and develop effective prevention and treatment regimens and drugs. This article reviews the pathogenesis of MAFLD from the aspects of genetic factors， improper diet and oxidative stress， spleen-stomach damp-heat and insulin resistance， damp-heat and pathogenic Qi， organic acid metabolism， and intestinal microecology.
Authors and Affiliations
Shukun YAO, Jing LIU, Tianhui ZHOU
Keywords
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- EP ID EP751077
- DOI 10.12449/JCH241005
- Views 25
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