Research advances of gamete and embryo-fetal origins of adult diseases
Journal Title: Biomedical Transformation - Year 2022, Vol 3, Issue 4
Abstract
The Development Origins of Health and Disease (DOHaD) theory suggests that adverse environmental factors in early life contribute to the development of chronic disease in adulthood. Compared to the intrauterine developmental period of the embryo and fetus, gametes take decades to develop and mature, and are more susceptible to potential damage. Changes in the gametes can be further transmitted to the offspring, leading to an increased risk of congenital anomalies and chronic adult disease in them, and intergenerational transmission effects can exist. Epigenetic modification refers to the regulation of gene expression without altering the nucleotide sequence, and the proposed doctrine offers the possibility of exploring the mechanisms of developmental-derived diseases. This paper summarizes the research progress of the gamete and embryo-fetal origins of diseases, and illustrates the important role of epigenetic mechanisms in this regard, and further emphasizes the importance of health interventions before conception and early in life to shift the primary prevention of diseases to the gametogenesis and intrauterine development of embryos and fetuses.
Authors and Affiliations
Zhao Yiran, Huang Hefeng
Keywords
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- EP ID EP766854
- DOI 10.12287/j.issn.2096-8965.20220404
- Views 13
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