Research and application of RNA interference in cataract
Journal Title: Guoji Yanke Zazhi - Year 2018, Vol 11, Issue 6
Abstract
RNA interference(RNAi)is the post-transcriptional gene silencing based on sequence-specific degradation of mRNA, and triggered by double-stranded RNA.RNAi technology is widely used in gene therapy and research of gene function and almost become a standardized technical tool with very broad prospect. The eyes with immune privilege are very suitable for the treatment of RNAi, which has been widely used for a variety of eye diseases, especially cataract. This paper briefly introduces the basic principle of RNAi technology and summarizes the recent research and application of this technology in cataract.
Authors and Affiliations
Wan - Rong Huang
Keywords
Related Articles
- EP ID EP558507
- DOI 10.3980/j.issn.1672-5123.2018.6.12
- Views 125
- Downloads 0
Vision distribution and its influencing factors of two teenager aviation schools in Western China
AIM: To analyze the vision distribution and its related risk factors of two teenager aviation schools in Western China. <p>METHODS: The study was a cross-sectional survey. A total of 233 participants were randomly select...
Corneal densitometry and its correlation with anterior and posterior elevation in keratoconus
AIM: To evaluate the corneal densitometry in treatment-naive patients with keratoconus and its relevance with anterior and posterior corneal elevation.<p>METHODS: Keratoconic corneas were examined using the Pentacam. Cor...
Efficacy of fundus photocoagulation combined with triamcinolone acetonide on diabetic retinopathy
AIM: To observe the efficacy of fundus photocoagulation combined with triamcinolone acetonide(TA)in the treatment of diabetic retinopathy(DR). <p>METHODS: The clinical data of 94 patients(112 eyes)in our hospital from Se...
Protective effect of pyridoxamine on RPE cells treated with AGEs
AIM: To observe the effects of pyridoxamine(PM)on RAGE, ROS and apoptosis in RPE cells treated with advanced glycation end products(AGEs), and to investigate the protective effect of PM on RPE cells in diabetic retinopat...
Relationship between autophagy and oxidative stress in diabetic retinopathy
Diabetic retinopathy(DR)is a microvascular and neurological complication of diabetes mellitus. Oxidative stress is an important pathogenic mechanism for the occurrence of DR. Autophagy is a crucial regulatory mechanism o...