RESEARCH OF ANTIOXIDANT AND PROOXIDANT PROPERTIES OF GLYCYRRHETIC ACID DERIVATIVES
Journal Title: International scientific journal Science and Innovation - Year 2023, Vol 2, Issue 7
Abstract
It was studied the effect of new synthetic derivatives of glycyrrhetic acid (GRA) on the functional mitochondrial parameters, as well as the parameters of the CsA-sensitive pore of mitochondrial membranes in the article. For the first time it was shown that GRA derivatives 2-(N-cytisine)-ethyl-3-0-acetyl-18H-glycyrrhetate (cytisine-ethyl-HC), 2-(N-cytisine)-isopropyl-3-0-acetyl-18H-glycyrrhetate (cytisine-isopropyl-HC) and N-(2-pyridyl)-3-0-acetyl-11-ketoolean-12-en-30-amide (2-pyridyl-HC-amide) inhibited the activity of the CsA-sensitive pore and have a protective effect on mitochondrial membranes. At the same time, the damaging effect of Ca2+ ions and the LPO process decreases. Other GRA derivatives are N-(4-pyridyl)-3-0-acetyl-11-ketoolean-12-en-30-amide (4-pyridyl-HC-amide) and 2-(N-morpholine)-ethyl-3-0-acetyl-18βH-glycyrrhetate (morpholine-HC) uncouples OXPHOS, enhances the damaging effect of inducers of the CsA-sensitive pore on membranes, increasing their permeability to cations
Authors and Affiliations
I. Ya. Sattarova, I. N. Chuliev, M. I. Asrarov, B. A. Niyazmetov
Keywords
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- EP ID EP719322
- DOI 10.5281/zenodo.8116684
- Views 46
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