Research of the rheological parameters of the combine compounding ointment with hydrocortisone butyrate
Journal Title: Фармацевтичний журнал - Year 2014, Vol 1, Issue 1
Abstract
Though the range of the industrial semi-solid preparations are quite wide, just compounding ointments allow to combine differences in pharmacological activity of the components in one preparation which provides versatile approach to the therapy. The Order № 812 of the Ministry of Health of Ukraine from 17. 10. 2012 allows to input industrial preparations to the compounding ointments. As all preparations irrespective of the preparation place have to meet the requirements on quality of the State Pharmacopoeia of Ukraine, the purpose of our study was to determine structural and mechanical properties of the combine compounding ointment prepared on the basis of industrial 1% hydrocortisone ointment and comparison of the rheological characteristics of both medicines. Objects of study were industrial 1% hydrocortisone ointment and compounding ointment on its basis: nitrofural 0,02; procaine hydrochloride 0,1; hydrocortisone ointment 1% to 10,0 g. Rheological properties of the samples were research with rotational viscometer Rheolab QC. Thermostatting of samples was done with help of thermostat MLM U15c. Inputment to the industrial 1% hydrocortisone ointment of nitrofural and procaine hydrochloride reduce its structural viscosity to 9,3% (Dr 0,01 s-1) and to 13,8% (Dr 350 s-1). This process doesn’t render a significant influence to the consumer properties of the ointment. The curves of fluidity testify that compounding ointment has pseudo-plastic type of a current, characterized by high plastic viscosity (3 210 Pa∙s) and low limit of fluidity (17,3 Pa). Big hysteresis square – 60 692,49 Pa∙s for the compounding ointment testifies to the its expressed plastic, viscous and thixotropic properties. The research of the rheological parameters of the combine compounding ointment with nitrofural, procaine hydrochloride, hydrocortisone ointment 1% was carried out. Compounding ointment has no significant deviations in structural and mechanical properties comparing with the industrial hydrocortisone ointment 1% which was used for its preparation.
Authors and Affiliations
L. P. Savchenko, V. О. Vrakin, G. P. Kukhtenko, V. А. Georgiyants
Keywords
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