Research of the toxicological profile of the new gel, which contains an extract of the oak bark and aloe extract
Journal Title: ScienceRise: Pharmaceutical Science - Year 2018, Vol 0, Issue 1
Abstract
<p>On these days periodontal diseases are widely distributed and diagnosed in more than 75 % of the world population and occurs in all age groups. Drugs based on medicinal plants should be considered as promising products, which have therapeutic effect with minimum adverse reactions.</p><p><strong>The aim</strong> of this work was to study the acute toxicity of new gel containing plant extract of oak bark and extract of aloe.</p><p><strong>Methods.</strong> Acute toxicity was studied in accordance with the guidelines on white nonlinear rats with 180–220 g in weight, by several steps: the study of acute toxicity of components of a new gel, the study of acute toxicity of a new gel under intragastric administration, intraperitoneal and skin administration.</p><p><strong>Results.</strong> It was established that it is not possible to determine LD<sub>50</sub> by intragastric administration of extract of oak bark and extract of aloe, since administration of a maximum dose of 15100 mg / kg did not cause lethality of rats. In order to confirm this assertion, in further studies the acute toxicity of extracts was studied only at a dose of 15100 mg / kg. In terms of intraperitoneally administration, LD<sub>50</sub> of extract of oak bark is 2580 (1930–3220) mg / kg, LD<sub>50</sub> of extract of aloe – 2180 (1460–2900) mg / kg. At the subsequent stages of the study during the observation for 14 days, there were no visible signs of the toxic effect of the new gel on the functional state of the animals at the maximum recommended doses: intragastric – 15100 mg / kg and skin application – 22600 mg / kg.</p><p><strong>Conclusions. </strong>The complex of the conducted studies allowed establishing that the new gel does not have a toxic effect on organs and systems of experimental animals and does not have a lethal action. Extract of oak bark and extract of aloe under conditions of intragastric administration are classified as VI class of toxicity "Relatively harmless substances". In case of intraperitoneally administration, the studied extracts were classified as V class of toxicity "Practically nontoxic substances". According to the study of acute toxicity, the new gel, in conditions of intragastric administration and skin application, belongs to the VI class of toxicity "Relatively harmless substances"</p>
Authors and Affiliations
Natalya Tsubanova, Dmytro Zhurenko, Tatiana Sakharova
Keywords
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- EP ID EP526810
- DOI 10.15587/2519-4852.2018.123978
- Views 186
- Downloads 0
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