RESEARCH ON THE CHOICE OF RATIONAL CONCENTRATION OF THE GEL FORMING AGENT IN THE COMPOSITION OF DENTAL GEL
Journal Title: Annals of Mechnikov Institute - Year 2019, Vol 0, Issue 2
Abstract
Taking into account the wide spreading and etiopathogenetic features of the course of inflammatory diseases of periodontium and oral mucosa, it is rational to use semisolid drugs of local action, namely, dental gels. The main issue when developing this dosage form is the choice of the gel former and its concentration. Based on previous studies as the gel basis for the development of a new dental gel with «Phytodent» tincture, choline salicylate 80%, and lidocaine hydrochloride the Carbomer Polacril® 40P, which is authorized for use in dentistry and has the ability to form transparent viscous aqueous-alcohol gels, has been chosen. It is known that rheological characteristics of gels directly affect the processes of release and absorption of active pharmaceutical ingredients from a semisolid dosage form, as well as its consumer properties. The important issue is the convenience and ease of application of a dental gel to inflamed tissues of periodontium and mucous membranes. This process is similar to that occurring during the shift of visco-plastic material in a rotary viscometer. The aim of the work is to study the structural and mechanical characteristics of the developed dental gel in order to select the rational concentration of the carbomer Polacril® 40P. Materials and methods. The study objects are gel samples with different concentrations of Carbomer Polacril® 40P – 1.0, 1.25, 1.5, 1.75 and 2.0 %. Measurement of the rheological parameters of the model gel samples was carried out at a temperature (25 ± 0.1) оС on a rotary viscometer with coaxial cylinders "Rheolab QC" ("Anton Paar") before and after contact with a solution of artificial saliva. As standards for comparison dental gels "Dentinox-gel N" (Germany) and gel "Metrogyl Denta®" (India) were selected. Results and discussion. It has been found that all gel samples have a non-Newtonian pseudoplastic flow type and are thixotropic systems with pronounced limits of fluidity. The rheological parameters of the dental gel samples increase as the concentration of Carbomer Polacril® 40P increases. In the nature of rheograms and structural viscosity the closest indicators to the drug "Dentinox-gel N" have gels with carbomer concentration of 1.25 % and 1.5 %, and to the drug "Metrogyl Denta®" – 1.75 % and 2.0 %. Conclusions. Taking into account the results of structural and mechanical studies of gels with and without an artificial saliva solution, as well as in terms of profitability, the optimal concentration of Carbomer Polacril® 40P in the composition of the developed gel was chosen to be 1.5 %.
Authors and Affiliations
O. A. , Ruban, Yu. S. Maslii
Keywords
Related Articles
- EP ID EP613719
- DOI 10.5281/zenodo.3265076
- Views 141
- Downloads 0
ANTIBACTERIAL ACTIVITY OF PHYTOSUBSTANTS FROM VACCINIUM VITIS-IDAEA LEAVES
The purpose of the work is to study the antibacterial activity of phytosubstances from Vaccinium vitis-idaea leaves. Materials and methods. The objects of the study were 13 phytosubstances, obtained from Vaccinium vitis-...
DEVELOPMENT OF THE POWDER COMPOSITION WITH THE SORBING, ANALGESIC AND ANTIMICROBIAL ACTIVITY BASED ON NATURAL ZEOLITE
Introduction. An active lifestyle, playing sports, participating in hiking trips and various competitions, as well as performing certain types of physical labor may be accompanied by injury. Damage of the skin requires i...
CREATION OF NEW MEDICAL DRUGS BASED ON TRIZ AND COMPUTER MATHEMATICAL MODELING
The article provides an overview of the current state of the use of TRIZ in the pharmaceutical industry and our R&D efforts in that area, based on TRIZ and computer mathematical modeling. Drug development is one of the m...
MICROBIOLOGICAL PARAMETERS IN PATIENTS WITH INFLAMMATORY COMPLICATIONS AFTER KNEE AND HIP JOINTS ENDOPROSTHESIS REPLACEMENT AND THEIR DIAGNOSTIC EVALUATION
Introduction. Presently in the inflammatory joint diseases diagnosis and treatment microbiological examination plays a leading role. This is due to the infectious diseases frequency general increase, the hospital infecti...
STUDY OF THE INFLUENCE OF A GEL FORMER (THICKENER) TYPE ON THE SORBTION KINETIC OF LONG-LIVING RADIONUCLIDES AND HEAVY METALS BY NATURAL ZELOLITE PASTE FROM AN AQUEOUS SOLUTION IN VITRO
Introduction. The deterioration of the population health, due to the chemicalization of many aspects of life, requires the development and introduction of new healing technologies. One of the modern areas of efferent the...