Research progress in the application of carbon dots in the diagnosis and treatment of ocular diseases
Journal Title: Eye Science (Yanke Xuebao) - Year 2024, Vol 39, Issue 4
Abstract
Carbon dots is a new type of fluorescent carbon nanomaterial, which the diameter is generally less than 10 nm, has the advantages of self-fluorescence, remarkable biocompatibility, easy modification, low cost and so on, has a broad application prospect in the biomedical field. Due to the unique barrier of the eye, conventional drugs have a short residence time and poor penetration, so the concentration of drugs that can reach the lesions through local eye drops is limited, and for what to increase the frequency of administration to maintain efficacy. Up to now, the treatment of posterior eye diseases, such as diabetic macular edema (DME), choroidal neovascularization (CNV) and other diseases still rely on repeated vitreous injection, which is an invasive procedure with potential complications, and need multiple injections, causing a heavy psychological and economic burden on patients. Optimizing the method of ocular drug delivery has always been a hot topic in the field of ophthalmology. Carbon dots have shown excellent application potential in the ocular drug delivery, ocular imaging, and diagnosis and treatment of ocular disease based on its excellent characteristics. This review will systematically introduce the characteristics of carbon dots and the application of carbon dots in the diagnosis and treatment of eye diseases, aiming to provide a comprehensive understanding of the current situation of the application of carbon dots in ophthalmology and provide directions for future research.
Authors and Affiliations
Yihan ZHAO, Yitong CHENG, Keyu LIU, Shiqiang LI, Wanna LI, Jiawei WANG
Application of continuous locking suture combined with corneal bandage contact lens in pterygium operation
[Objective:] To investigate the effect of continuous locking suture combined with corneal bandage lens in the operation of pterygium. [Methods:] A prospective randomized controlled clinical trial was conducted. From Janu...
Epidemiological analysis of emergency ophthalmic cases in a specialist hospital in Tianjin
[Objective] To analyze the disease spectrum of emergency cases at an ophthalmology hospital in Tianjin, offering evidence-based support for standardizing diagnostic procedures and rationing emergency medical resources. [...
Research progress of organelle degradation and its mechanisms during lens development
During terminal differentiation of lens fiber cells, nuclei and other organelles experience programmed elimination. This process is essential for the maintenance of lens transparency. However, the mechanisms underlying l...
Progress in the diagnosis and treatment of neuromyelitis optica spectrum disorder optic neuritis
Neuromyelitis optica spectrum disorder- optic neuritis (NMO-ON) is a common type of optic neuritis (ON). This affliction is predominant in female non-Caucasians, with severe injury, more bilateral involvement, and poor v...
Two cases of microphthalmia caused by MAB21L2 gene mutation and a systematic review of genotype-phenotype associations of MAB21L1 and MAB21L2
[Objective:] To summarize the genetic variations and clinical features of the MAB21L2 and compare them with the highly homologous MAB21L1 gene. [Methods:] A genotype -genotype analysis was performed on the patients with...