Research progress of cell therapy in the preservation and functional repair of donor livers
Journal Title: Biomedical Transformation - Year 2023, Vol 4, Issue 3
Abstract
Liver transplantation is the most effective treatment for end-stage liver diseases. However, the shortage of donor livers severely restricts the application of liver transplantation, and the impairments of liver function caused by intraoperative ischemia reperfusion injury and postoperative immune rejection also significantly affect the therapeutic efficacy. In order to improve the shortage of donor livers and further improve the efficacy of liver transplantation, a variety of cell therapies based on stem cells or somatic cells have been tried to repair and improve donor liver function. At present, the time points for cell therapy can be divided into the stage before procurement of donor livers, machine perfusion stage and stage after reperfusion of donor livers. In this review, we summarize the efficacy and the underlying mechanisms of cell therapy in the preservation and function repair of donor livers, so as to facilitate the application and promotion of cell therapy in the field of liver transplantation.
Authors and Affiliations
Qiu Xun, Xu Hanzhi, Wang Kai, Xu Xiao
Keywords
Related Articles
- EP ID EP766392
- DOI 10.12287/j.issn.2096-8965.20230307
- Views 9
- Downloads 0
Research progress and application of artificial intelligence technology in lung cancer diagnosis
The use of artificial intelligence in the medical field has become increasingly widespread, particularly in the diagnosis of lung cancer. Early and accurate diagnosis of lung cancer is crucial for effective treatment and...
Hyperglycemia promotes Alzheimer's disease-like pathological changes by upregulating the CDK5 expression through AMPK/SIRT1 action
Inflammatory bowel disease (IBD) includes ulcerative colitis (UC) and Crohn's disease (CD). Malnutrition is common in patients with IBD. Compared with UC, more severe malnutrition often occurs in CD. The prevalence of sa...
The management strategies for gastric precancerous conditions and precancerous lesions
Although gastric cancer rates have been reported to have declined in recent years, it remains the fifth leading cause of cancer death worldwide. Patients with advanced gastric cancer often face extremely limited treatmen...
Update on the potential role and its regulatory mechanism of iron metabolism and ferroptosis of cardiomyocytes in cardiomyopathy
It has been demonstrated that cardiomyocyte metabolism and cell death are the fundamental progresses in the development of cardiomyopathy. Increasing evidences suggest that metabolic imbalance of iron appears to be invol...
Single-cell transcriptomics technology and its application in limb regeneration research
Salamanders have a strong ability to regenerate limbs, while this potential is progressively declined in frogs during development. With evolution, adults of humans and other mammals completely lose the ability to regener...