Research progress of nanomaterials in nose-to-brain delivery for glioblastoma treatment
Journal Title: Chinese Journal of Nervous and Mental Diseases - Year 2024, Vol 50, Issue 3
Abstract
Glioblastoma (GBM) stands as one of the most aggressive brain tumors, and its pharmacological therapy is severely limited due to the presence of the blood-brain barrier (BBB). Nose-to-brain drug delivery has emerged as a promising approach for directly targeting the central nervous system (CNS) by circumventing the BBB. The nasal cavity is anatomically partitioned into the vestibular, olfactory, and respiratory regions. Nanomedicines can efficiently transport to the CNS through the olfactory pathway of the olfactory region and the trigeminal nerve pathway of the respiratory region. In recent years, nanodelivery platforms in nasal administration for treating GBM have garnered widespread attention, primarily involving polymers, liposomes, inorganic metal nanoparticles, and so on. The advancement of these technologies presents novel avenues and selections for overcoming the BBB, enhancing drug delivery efficacy, and improving the prognosis of GBM patients.
Authors and Affiliations
Zibin SONG, Jiajie YUAN, Yunjiao CHEN, Jianfeng LI, Jun. PAN
Keywords
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- EP ID EP750453
- DOI 10.3969/j.issn.1002-0152.2024.03.013
- Views 1
- Downloads 0
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