Research progress on autoimmune glial fibrillary acidic protein astrocytopathy
Journal Title: Chinese Journal of Nervous and Mental Diseases - Year 2024, Vol 50, Issue 12
Abstract
Autoimmune glial fibrillary acidic protein astropathy (GFAP-A) is an autoimmune inflammatory disease of the central nervous system, with a prevalence rate of 0.6 per 100,000. Its clinical manifestations include subacute meningitis, encephalitis, myelitis, or combinations thereof. Approximately 40% of patients exhibit symptoms and signs of prodromal infection such as fever and headache, while 30% may develop tumors. Currently, diagnosis primarily relies on the presence of GFAP-IgG in cerebrospinal fluid. Differential diagnosis must exclude conditions such as central nervous system vasculitis, inflammatory demyelinating diseases, lymphoma, glioma, and brain metastases, posing significant challenges in clinical practice. This paper summarizes the clinical manifestations, diagnosis, and treatment of GFAP-A to enhance understanding of the disease and prevent misdiagnosis.
Authors and Affiliations
Jiajia JIANG, Wenxuan WANG, Yi YANG, Yajing LIU, Shuanghao FENG, Hui BU
Keywords
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- EP ID EP759214
- DOI 10.3969/j.issn.1002-0152.2024.12.009
- Views 50
- Downloads 0
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