Research progress on liposomes and periodontal disease
Journal Title: 口腔疾病防治 - Year 2019, Vol 27, Issue 10
Abstract
Liposomes are microspheres that are similar to cell membranes. They have good sustained release, biocompatibility and targeting ability and can reduce the toxicity of encapsulated drugs. This article reviews the research progress of the use of liposomes in periodontal drug delivery systems and periodontal tissue engineering scaffolds. Liposomes have shown unique advantages and broad prospects in the field of periodontal drug delivery. Liposomes loaded with bioactive molecules and combined with periodontal tissue engineering scaffolds can improve the pharmacokinetics and local efficacy of these molecules. Modification of various extracellular matrix proteins on the surface of the scaffolds can promote the absorption of liposomes. Attachment of these proteins to the surface of the scaffold can reduce the requirement for bioactive molecules, improve the effective conversion rate and prolong the half-life of the scaffold in vivo. However, the development, clinical efficacy and safety evaluation of new liposomes still need to be further explored.
Authors and Affiliations
CHENG Guoping, DING Yi, GUO Shujuan
Keywords
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- EP ID EP673015
- DOI 10.12016/j.issn.2096-1456.2019.10.009
- Views 159
- Downloads 0
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