Research progress on nasal administration technologies of traditional Chinese medicine
Journal Title: China Powder Science and Technology - Year 2024, Vol 30, Issue 5
Abstract
Progress Various nasal dosage forms of TCM have been developed， including nasal drops， lotions， emulsions， aerosols， sprays， powder sprays， sniffing agents， gels， and films. Among them， nasal drops are easy to prepare and cost-effective， but have some shortcomings such as inaccurate dosage， uneven distribution， and easy loss in the nasal cavity. Powder sprays， which do not require propellants and pressure devices， are environmentally friendly， more stable， and have sustained and controlled release. However， they may not deliver the drug effectively to nasal cavity due to varying particle sizes. Aerosols and sprays distribute evenly， are not easily lost， and can achieve bioavailability of 70%~80%. However， they require special injection valve systems and specific containers， which are costly to manufacture and contain propellants that may cause mucosal irritation. Gels， films， and microemulsions can extend the residence time of the drug in the nasal mucosa， improving bioavailability and reducing the administration frequency while increasing drug loading. However， their preparation processes are complex， and their efficacy is unstable. The paper reviews the characteristics and applications of TCM nasal dosage forms， including nasal drops， aerosols， powders， gels， film agents， microemulsions， introduces the theoretical basis， and summarizes the research progress in pharmacology， pharmacokinetics， quality control， irritant studies， and device development. Significance Nasal drug delivery technology of traditional Chinese medicine （TCM） is a new administration method where Chinese herbal medicines are prepared and placed in the nasal cavity in a certain dosage form and absorbed by the nasal mucosa to exert local or systemic therapeutic effects. Compared to traditional dosage forms such as injections or oral preparations， nasal drug delivery has the advantages of convenient administration， good targeting， high safety， and fast absorption. It is particularly effective for the treatment of upper respiratory tract infection and other diseases. Therefore， this technology has been widely used in recent years and has become a hot spot in the research and development of new TCM drug delivery systems. Current TCM nasal drug delivery systems face several challenges
Authors and Affiliations
Wenlong LI, Jiahao FENG, Wenliang DONG, Xin SHA, Wei CHEN, Guifang ZHOU
Keywords
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- EP ID EP749286
- DOI 10.13732/j.issn.1008-5548.2024.05.008
- Views 19
- Downloads 0
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