Research progress on pathobiology of myofibroblast in wound healing after glaucoma filtering surgery
Journal Title: Guoji Yanke Zazhi - Year 2018, Vol 18, Issue 10
Abstract
Glaucoma filtering surgery is the main treatment for the glaucomatous patients. Typically, surgery failed mary due to wound fibrosis and contracture at the post-surgical site.Myofibroblasts transdifferentiated from other cells via a process known as epithelial-mesenchymal transition(EMT)is a common feature of the fibrotic filtering channel, which can produce excessive amounts of the extracellular matrix(ECM), and then exert tractional forces, resulting in the disruption of tissue architecture and obstruction of filtering channel. In this review, we explain the pathological function of myofibroblast in the wound healing process after glaucoma filtering surgery.
Authors and Affiliations
Ke Li
Keywords
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- EP ID EP525730
- DOI 10.3980/j.issn.1672-5123.2018.10.11
- Views 144
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