Research progress on the relationship between fibroblast growth factor and choroidal neovascularization
Journal Title: Eye Science (Yanke Xuebao) - Year 2020, Vol 35, Issue 2
Abstract
Choroidal neovascularization (CNV) can be found in ophthalmic diseases, such as age-related macular degeneration (AMD) and pathological myopia, which is an important cause of the development, deterioration and visual impairment of many fundus diseases. Many growth factors can promote the incidence and progression of CNV, including vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF), transformation growth factor (TGF), insulin growth factor (IGF) and connective tissue growth factor (CTGF), etc. Among them, VEGF is the most important factor that promotes neovascularization. In recent years, anti-CNV measures, such as laser treatment and anti-VEGF drugs, have been adopted. However, anti-VEGF drugs yield drug resistance and certain adverse events. The pathogenesis of CNV has not been completely understood. FGF can exert both direct and indirect effects on fibroblasts and endothelial cells, and promote the CNV. FGF family-related factors may become new targets for CNV therapy, which may provide other options besides anti-VEGF therapy alone.
Authors and Affiliations
Lele LI, Manhui ZHU, Zhaoxian QIU, Aimin SANG
Keywords
Related Articles
- EP ID EP763402
- DOI 10.3978/j.issn.1000-4432.2020.04.03
- Views 17
- Downloads 0
Research progress on the application of oxybuprocaine hydrochloride eye drops in ophthalmology
Most ophthalmic surgeries are characterized by small incisions and mild pain, therein, the choice of topical anesthesia can meet the needs of surgeries and accelerate ophthalmic surgeries to be conducted in day surgery m...
Orbital and cranial communicating hydatid disease: A case report
A young female patient complained of recurrent redness and swelling of the right eyelid for more than 3 months. Orbital CT examination showed that low density soft tissue density shadow with clear boundary can be seen in...
Experience in the treatment of a case of complex corneal blindness
Keratoconus is a common disease in ophthalmology and treatment is mainly based on etiology. Untreated corneal diseases can develop into corneal clouding, corneal macula, corneal leukoplakia or even loss of vision. This i...
An ophthalmological surgery drape
In order to make ophthalmic surgical draping safer, more convenient and easier to operate, this research team invented an ophthalmic surgical drape [patent number: National Utility Model Patent (ZL 201921410018.3)] based...
A case report of corneal burn caused by arc light
A case of corneal burn caused by arc light due to electrical short is reported. Specialist examination: ischemic areas of the temporal limbus bulbar conjunctiva in both eyes were less than 1/3, the corneal epithelium was...