Resistin: A pathogenic factor or a biomarker of metabolic disorders and infl ammation?
Journal Title: Advances in Hygiene and Experimental Medicine - Year 2009, Vol 63, Issue
Abstract
Cardiovascular diseases are currently the most frequent cause of death in Poland and their incidence continually rises. This is related to the high incidence of obesity associated with insulin resistance, which is present in type 2 diabetes mellitus. Adipose tissue produces multiple cytokines (TNF-alpha, IL-6, PAI-1, CRP, angiotensinogen, leptin, adiponectin, visfatin, apelin, resistin) which decrease insulin sensitivity and induce infl ammatory processes, endothelial dysfunction, and atherosclerosis. This article presents the link between obesity, insulin resistance, and type 2 diabetes mellitus according to studies conducted in vitro and in animal models. In human studies, the infl uence of resistin on the development of insulin resistance is controversial. The article underlines the role of resisitin in the development of infl ammatory processes and endothelial dysfunction in humans. In clinical studies, resistin was shown to be a predictive factor of coronary artery disease and mortality connected with cardiovascular diseases.
Authors and Affiliations
Aleksandra Karbowska, Maria Boratyńska, Marian Klinger
Keywords
Related Articles
- EP ID EP66386
- DOI -
- Views 146
- Downloads 0
Role of tumor microenvironment in the formation and progression of skin melanoma
Melanoma develops from melanocytes localized mainly in skin, to a lesser extent in uvea and mucosal tissue. It is one of the most aggressive tumors, resistant to standard therapies. It is caused mainly by UV radiation. A...
The formation, metabolism and the evolution of blood platelets
Platelets are the smallest, depleted of nucleus blood cells which contain a typical cellular organelles including the mitochondria, so that have active metabolism. Platelets possess the highly organized cytoskeleton, spe...
Juvenile idiopathic arthritis and oral health
Juvenile idiopathic arthritis (JIA) is the most common autoimmune inflammatory disease of connective tissue in children. It is characterized by progressive joint destruction which causes preserved changes in the musculos...
Rho proteins − the key regulators of cytoskeleton in the progression of mitosis and cytokinesis
The Rho proteins are members of the Ras superfamily of small GTPases. They are thought to be crucial regulators of multiple signal transduction pathways that influence a wide range of cellular functions, including migrat...
18 kDa białko translokatorowe – implikacje w funkcje komórki
Mitochondrialne białko translokatorowe (18 kDa –TSPO) po raz pierwszy wyizolowano w 1977 r. podczas badania zdolności wiązania diazepamu w tkankach obwodowych. Nazwą bardziej znaną jest wcześniej używany termin − recepto...