Result of tranexamic acid in controlling blood loss in total knee and hip replacement surgery
Journal Title: International Journal of Orthopaedics Sciences - Year 2018, Vol 4, Issue 2
Abstract
Background: Blood loss is one of the major problems during intra-operative and postoperative periods after doing total knee and hip replacement. It is associated with high perioperative blood loss between 700 to 2,000 ml. High blood loss can lead to a longer hospital stay, impedes rehabilitation and may be poorly tolerated by patients with cardiovascular diseases (CVD). Aims and Objective: To evaluate the effect of intravenously administered tranexamic acid (TXA) in controlling blood loss in total knee and hip replacement surgery. Materials and Methods: Fifty patients undergoing total knee arthroplasty (TKA) and total hip arthroplasty (THA) were studied from April 2014 to March 2016 after dividing them into Group 1 (n=25; total hip replacement) and Group 2 (n=25; total knee replacement). All patients received TXA10 mg/kg 15 min before incision. As a primary outcome transfusion incidence, drain output, postoperative hemoglobin and hematocrit drop were evaluated. As a secondary outcome incidence of symptomatic deep vein thrombosis and pulmonary embolism within 30 days of surgery were evaluated. Results: Female preponderance was noted (60%). Pre operative hemoglobin was higher (11.72 gm%) as compared to post operative hemoglobin at 2nd (9.9 gm%) and 4th day (9.5 gm%) of surgery in Group 1 as well as in Group 2 pre operative hemoglobin was higher (11.78 gm%) as compared to post operative hemoglobin at 2nd (9.6 gm%) and 4th day (9.3 gm%). Drain (ml) output in Group 1 and Group 2 was 150.2 and 170.4 ml respectively. Blood transfusion was required only in one patient in Group 2. Conclusion: TXA administered through intra venous route was found to decrease postoperative bleeding and requirement of transfusion in unilateral TKA and THR without increasing any risk of complications
Authors and Affiliations
Dr. Pradeep Kumar Saini, Dr. Sanat Singh, Dr. Ranjan Sinha
Keywords
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- EP ID EP486833
- DOI 10.22271/ortho.2018.v4.i2i.83
- Views 80
- Downloads 0
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