Resveratrol, a natural phenolic compound may reduce carbonylation proteins induced by peroxynitrite in blood platelets.

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Resveratrol, a natural phenolic compound may reduce carbonylation proteins induced by peroxynitrite in blood platelets.

Journal Title: General Physiology and Biophysics - Year 2006, Vol 25, Issue 2

Abstract

Resveratrol (3,4',5-trihydroxystilbene) has a very broad range of biological properties, including antiplatelet and antioxidative activity. We investigated in vitro the effect of resveratrol on carbonylation of proteins (indicators of oxidative stress) in blood platelets treated with peroxynitrite (ONOO(-)), a strong biological oxidant and inflammatory mediator. We observed that carbonylation of proteins induced by ONOO(-) (0.1 mmol/l), in the presence of resveratrol (0.25-0.1 mmol/l) is reduced. Resveratrol may scavenge ONOO(-), and may be useful in the prevention of ONOO(-)-related diseases, such as inflammatory and cardiovascular diseases.

Authors and Affiliations

B Olas, P Nowak, M Ponczek

Keywords

Antioxidants - pharmacology Blood Platelets - drug effects Blood Platelets - metabolism Carbon - chemistry Colorimetry Enzyme-Linked Immunosorbent Assay Humans Inflammation Lipid Peroxidation Oxygen - chemistry Peroxynitrous Acid - chemistry Phenol - chemistry Platelet Adhesiveness - drug effects Platelet Aggregation - drug effects Platelet Aggregation Inhibitors - pharmacology Stilbenes - pharmacology

Resveratrol, a natural phenolic compound may reduce carbonylation proteins induced by peroxynitrite in blood platelets.

EP ID EP140546
DOI -
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