Reticulocyte hemoglobin content as a predictor of iron deficiency anemia

Journal Title: Paediatrica Indonesiana - Year 2015, Vol 55, Issue 3

Abstract

Background Iron deficiency anemia (IDA) is the most common form of anemia in developing countries, such as Indonesia. Iron deficiency anemia in children is a serious problem because it affects their growth and development. Early detection of IDA and subsequent treatment in childhood may prevent future health problems.Objective To assess the use of reticulocyte hemoglobin content (CHr) to detect IDA in children aged 6-60 months.Methods We performed a cross-sectional study to measure the sensitivity and specificity of CHr compared to serum ferritin which is considered to be the gold standard for IDA diagnosis. The study was conducted from September 2011 to March 2013 in children aged 6-60 months who visited the Pediatric Outpatient Clinic, Sanglah Hospital, and Puskesmas II in West Denpasar. Data analysis was performed by 2x2 table. The results were assessed by area under the curve (AUC) and receiver operating characteristic (ROC).Results Of 121 children underwent blood testing during the study period, 69 children were excluded because they did not have hypochromic microcytic anemia, leaving 52 subjects eligible for the study. The prevalence of IDA in this study was 31%. Reticulocyte hemoglobin content (CHr) ≤ 23.1 pg had 88% (95%CI 71 to 100%) sensitivity and 25% (95%CI 11 to 39%) specificity.Conclusion Reticulocyte hemoglobin content < 23.1 pg may be a good predictor of IDA.

Authors and Affiliations

Ni Made Suari, Ketut Ariawati, Nyoman Adiputra

Keywords

Related Articles

Blood pressure-to-height ratio for diagnosing hypertension in adolescents

Background Diagnosing hypertension in children and adolescents is not always straightforward. The blood pressure-to-height ratio (BPHR) has been reported as a screening tool for diagnosing hypertension.Objective To evalu...

Correlation between nucleated red blood cells and pulse oxygen saturation in neonatal asphyxia

Background Neonatal asphyxia is the major cause of neonatal death at a rate of approximately 23%. The incidence of asphyxia is higher in developing countries, due to limited availability of perinatology facilities. Hypox...

High sensitivity C-reactive protein, left ventricular mass, and systolic function in obese adolescents

Background Obesity has been associated with structural and functional cardiac muscle defects. High sensitivity C-reactive protein (hs-CRP) has been utilized as an independent predictor of future cardiovascular disease.Ob...

Waist circumference and insulin levels in obese children

Background Childhood obesity is one of the most serious public health challenges of the 21st century. Its prevalence has increased at an alarming rate. Overweight and obese children are prone to obesity in adulthood and...

Body mass index, atopy, and allergic diseases

Background Prevalence of atopy, allergic diseases, and obesity are increasing. Atopy is an individu and/or familial tendency to sensitization in response to ordinary exposure to allergens. Studies on association of BM I...

Download PDF file
  • EP ID EP448545
  • DOI 10.14238/pi55.3.2015.171-5
  • Views 70
  • Downloads 0

How To Cite

Ni Made Suari, Ketut Ariawati, Nyoman Adiputra (2015). Reticulocyte hemoglobin content as a predictor of iron deficiency anemia. Paediatrica Indonesiana, 55(3), 171-5. https://europub.co.uk/articles/-A-448545