RETROSPECTIVE ANALYSIS OF NEPHROTOXICITY BY CISPLATIN IN PATIENTS WITH CANCER OF CERVIX DURING THE TREATMENT OF CISPLATIN AND CONCURRENT RADIOTHERAPY
Journal Title: GJRA-Global Journal For Research Analysis - Year 2019, Vol 8, Issue 3
Abstract
PURPOSE: To evaluate acute renal toxicity during the simultaneous administration of cisplatin-radiotherapy as treatment in cervical cancer in women under and over 50 years. METHODS: Women with a diagnosis of cervical cancer with clinical stage IB1 to IVA, and even patient with clinical stage IVB who after systemic treatment had persistent disease locally, treated with Radiotherapy and weekly cisplatin. It was grouped into adults over and under 50 years old to evaluate the incidence of renal failure according to the age of decrease in physiological glomerular ltration rate. In whom a retrospective - descriptive statistical analysis was performed with the program SPSS V.21, EXCEL 2010 and "R" program, to compare the stages of weekly AKIN globally regardless of age and dividing into women under and over 50 years old. The ANOVA test was applied to compare the weekly creatinine levels globally in the entire study group and separate them into groups of people under and over 50 years old. The Friedman test and the Kruskal Wallis test were applied with an alpha of 0.05 in order to compare the weekly AKIN stages globally regardless of the ages as well as lost patients under the SPSS program. RESULTS: Using the Friedman test (alpha = 0.05 and a condence interval of 95%) according to the AKIN scale, a non-signicant value (p = 0.477) was obtained, so there is no increase in the incidence of acute renal failure in the studied population. With the Kruskal Wallis test, measuring the difference of acute renal failure and taking the population as a whole, a value of (p = 0.599) was obtained. When comparing women under and over 50 years old in regard to the incidence of acute renal failure, taking into account the aging process in renal physiology, a value of (p = 0.118) was obtained for the group under 50 years old and a value of (p = 0.6014) for the group over 50 years old. CONCLUSION: Age greater than 50 years, although it seems to have a greater tendency to present renal involvement during treatment, at the moment at standard doses of treatment, does not present a major effect, however, renal function must be constantly monitored and looked after.
Authors and Affiliations
Leonardo David Villacrés, Federico Narvaez, Vásquez Proaño Elisa, Mery Acuña, Vega Cañarejo Gabriel, Villagrán Ochoa Grace, Pillajo Balladares Diana, María Elena Urresta
Keywords
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