Retrospective Comparison of Estimated GFR using 2006 MDRD, 2009 CKD-EPI and Cockcroft-Gault with 24 Hour Urine Creatinine Clearance
Journal Title: Journal of Clinical and Diagnostic Research - Year 2017, Vol 11, Issue 5
Abstract
Introduction: The assessment of Glomerular Filtration Rate (GFR) is essential for clinical practice in assessing kidney function, drug dosing, detecting and estimating the prognosis of Chronic Kidney Disease (CKD). The most common practical method for assessing GFR is performed with a 24 hour/ timed urine collection for creatinine clearance evaluation. The estimation of eGFR by creatinine based formulae is known to be a rapid and reliable means of approximation of creatinine clearance. Aim: To compare eGFR using three commonly used Formulae {Modification of Diet in Renal Disease Study Equation (MDRD 2006), Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI 2009) and Cockcroft-Gault Formula} with 24 hour creatinine clearance and to identify which amongst the 3 formulae for eGFR closely correlates with 24 hour creatinine clearance in a secondary care hospital. Materials and Methods: We retrospectively collected laboratory data requested for 24 hour creatinine clearance in the period from January 2014 to August 2016. Totally 91 laboratory request for 24 hour creatinine clearance data were obtained. The pairedt-test was used for comparison since all parameters used in the study were numerical, all patients came from same population and all had paired results. Results: The eGFR by MDRD formulae had a statistically insignificant p-value (p > 0.05) i.e., good approximation in the IInd, IIIrd, IVth and Vth stages of CKD on comparison with 24 hour creatinine clearance. The eGFR by CKD-EPI formulae had a statistically insignificant p-value (p > 0.05) in the IInd, IVth and Vth stages of CKD. The eGFR by Cockcroft-Gault Formulae had a statistically insignificant p-value (p > 0.05) in the Ist, IInd and Vth stages of CKD. Conclusion: The Creatinine based GFR estimation provides a more accurate assessment of 24 hour creatinine clearance and kidney function than measuring serum creatinine alone but have certain limitations in few clinical circumstances. No single equation will be optimal for all populations. But the result of this study showed MDRD 2006 formulae to be more accurate than CKD-EPI 2009 and Cockcroft-Gault formulae in estimating GFR, detection of CKD, drug dosing and estimating prognosis.
Authors and Affiliations
B. VINODH KUMAR, THUTHI MOHAN
Keywords
Related Articles
- EP ID EP341169
- DOI 10.7860/JCDR/2017/25124.9889
- Views 69
- Downloads 0
Story of a Giant Endometrial Polyp in Asymptomatic Postmenopausal Female
Endometrial polyps are localized overgrowth of endometrial glands and stoma through the uterine cavity. They are associated with postmenopausal bleeding, infertility and menorrhagia and are affected by unbalanced oestrog...
Yoga Based Lifestyle Program in Improving Quality of Life after Coronary Artery Bypass Graft (CABG) Surgery: A Randomised Controlled Trial
ABSTRACT Introduction: The Quality of Life (QOL) after Coronary Artery Bypass Grafting (CABG) is an important contributor to morbidity and mortality. The addition of Yoga Based Lifestyle Program (YLSP) to conventional ca...
Radiation Dose Reduction and Cancer Risk Estimation Associated with Upper Limbs Radiographic Examination by using Optimal Projections: A Phantom Study
ABSTRACT Introduction: Ionising radiation used during medical imaging examinations should be monitored carefully to reduce the radiation harm and biological effects. In radiography, As Low As Reasonably Achievable (ALARA...
Dexmedetomidine as an Adjuvant to Ropivacaine in Ultrasound Guided Paediatric Caudal Epidural Block: A Randomised Controlled Study
ABSTRACT Introduction: Caudal epidural block is a reliable technique to provide perioperative analgesia for infra-umbilical surgeries in paediatric population. Several adjuvants are used along with local anaesthetics to...
Is there a Correlation between Micronutrients and Cognitive Status: An Exploratory Study of Senile Dementia of Alzheimer’s Type
ABSTRACT Introduction: Alzheimer disease is a multifarious neurodegenerative disorder which is a leading cause of dementia in late adult life. It is characterised by deposition of intracellular neurofibrillary tangles an...