REVELATION OF MECHANISM OF ACTION OF RHIZOPHORA MUCRONATA POIR. BARK EXTRACT FOR ITS ANTIDIABETIC ACTIVITY BY GUT PERFUSION AND SIX SEGMENT METHOD IN LONG EVANS RATS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2013, Vol 4, Issue 5
Abstract
The aqueous bark extract of Rhizophora mucronata Poir. is used in Bangladesh as a hypoglycemic aid without any knowledge about its probable mode of action . It is an effort to assess the claimed hypoglycemic property of the crude drug and to get some knowledge about it. The Hypoglycemic effects were investigated in the ethanol extract of bark of Rhizophora mucronata Poir on Long Evans rats. Gut perfusion and six segments studies were carried out to assess these activities. In gut-perfusion study the percentage of glucose absorption in control rats vs. rats fed with 500 mg/kg extracts were observed at 5, 10, 15, 20, 25 and 30 minutes and the significant (p<0.05) absorption result was found which were respectively 30.71 vs. 56.34, 36.87 vs. 71.30, 35.87 vs. 62.11, 36.64 vs. 70.44, 36.36 vs. 64.21, 35.24 vs. 56.32, The percentage drug unabsorbed in GIT was better with 500 mg/kg than 250 mg/kg. The six-segment study was performed to assess the amount of sucrose remaining in the GIT at six different positions. The amount of sucrose unabsorbed in different GIT segments showed that in control rats vs. rats fed with 500mg/kg extract at 30 minutes in mmol/l was 0.1526 vs. 0.1767 which gradually abating with time dependent manner at 60, 180, and 360 minutes in mmol/l. These results suggests Rhizophora mucronata bark has significant dose dependant anti-diabetic effects, which significantly suppressed postprandial hyperglycemia after sucrose ingestion and reversibly increases the unabsorbed sucrose content throughout the gut.
Authors and Affiliations
Mahamudul Haque, Asma Ahmed, Shamema Nasrin, Md. Rahman, Shaikh Raisuzzaman
Keywords
Related Articles
- EP ID EP87496
- DOI 10.7897/2230-8407.04522
- Views 120
- Downloads 0
TOXICOLOGICAL STUDIES OF FICUS VIRENS IN WISTAR ALBINO RATS
The present study was conducted to investigate the toxic effect of oral administration of methanolic leaf extract of Ficus virens in Wistar albino rats.The phytochemical analysis of the F.virens extract was carried out u...
SIMULTANEOUS EQUATION METHOD AND Q-ABSORPTION RATIO METHODS DEVELOPMENT AND VALIDATION OF KETOTIFEN FUMARATE AND THEOPHYLLINE IN BULK AND DOSAGE FORM
A simple, accurate and precise UV- Spectroscopy method for the simultaneous estimation of Ketotifen fumarate and theophylline in Bulk and Dosage form has been developed and validated. Absorbance of ketotifen fumarate and...
INTERACTIVE POTENTIAL OF CLARITHROMYCIN IN RATS ADMINISTERED WITH GLICLAZIDE IN NORMAL AND DIABETIC CONDITIONS
To investigate the interaction between clarithromycin and gliclazide, the present study is designed in various animal models. Albino rats and rabbits were selected for the current study. The animals were suitably grouped...
NOVEL BIOACTIVE COMPOUNDS FROM MANGROVE DERIVED ACTINOMYCETES
Mangrove is most productive and unexplored ecosystem that approximately covers one fourth of world coastline with high diversity of thriving organism. Recently the rate of isolation of novel bioactive compounds from micr...
BEHAVIORAL MODELS OF PSYCHOSISA
Existing research into schizophrenia has remained highly fragmented, much like the clinical presentation of the disease itself. Differing theories as to the cause and progression of schizophrenia, as well as the heteroge...