Review Article on Valsartan
Journal Title: International Journal of Trend in Scientific Research and Development - Year 2020, Vol 4, Issue 6
Abstract
A simple, sensitive, rapid and reproducible HPLC method has been developed and validated for Calibration determination of Valsartan in bulk and in pharmaceutical formulation by applying Quality intentionally. For development of HPLC method for Valsartan various trials are performed by using Design Expert software by applying 3 level factorial designs. Quantitative method development by optimization from trials intentionally Expert software. The Optimized method Desirabilityis0.998 for Mobile Phase ACN Phosphate Buffer 65 35 in3.5 pH at maximum Wavelength 274nm at column oven temperature 40°C. The flow of mobile phase was adjusted 1.0 ml min. and therefore the injection volume 10 µl. Optimised Standard curve showed a parametric statistic is 0.998. Retention time was found to be 4.6 min. the half of recovery was found to be within the bounds of the acceptance criteria with average recovery of 99.4 you take care of Valsartan. The tactic was validated as per ICH guidelines. The precision and repeatability results showed RSD but 2 . The developed method was successfully validated in consistent with ICH guidelines. Hence, these methods are often conveniently adopted for the routine analysis in internal control laboratories. Mr. Sandeep Markad | Dr. Amit Kasabe | Dr. Ashok Bhosale "Review Article on Valsartan" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-4 | Issue-6 , October 2020, URL: https://www.ijtsrd.com/papers/ijtsrd33435.pdf Paper Url: https://www.ijtsrd.com/pharmacy/analytical-chemistry/33435/review-article-on-valsartan/mr-sandeep-markad
Authors and Affiliations
Mr. Sandeep Markad
Keywords
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