Review: Cytohistophysiological Aspects of Blood Organ/Tissue Barriers
Journal Title: Advances in Clinical Toxicology - Year 2024, Vol 9, Issue 3
Abstract
General physiology is the basis of basic and applied aspects of life processes and moleculo-biochemical aspects that ensures the survival of species efficiently. There is a need to maintain specific amount and numbers of metabolites in the body fluid and the fluid present in the organs. This needs a specific check on the body fluid that provides the required metabolites and removes unwanted ones. For this scrutiny, there is something like a ‘check post’ and it is referred to as ‘blood organ/tissue barrier’. Further, this ensures the restoration of appropriate ambient environment for the ongoing physiological processes in an organism. Structural, biochemical and molecular aspects of blood organ barriers have potential to illustrate on the survival mechanisms. Further, biotechnological research, artificial mode of physiological techniques and the technological advancement help to understand the intricacies of various physiological mechanisms occurring in the life activities and the remedial aspects in cases of pathogenesis. For normal physiological functioning a suitable physiological homeostasis is an important basis. The respective balanced biochemical and molecular interactions depend on processes like paracellular diffusion of metabolites, activated transport of hydrophobic and hydrophilic metabolites and drugs from the circulating blood stream. There is a specific need of an effective drug therapy along with appropriate drug delivery system that can regulate the correct dose of drug at the site to meet the remedial parameters while dealing with pathogenesis and dysfunctioning of the organ. The investigations relating blood barrier are significant while investigation the toxicological and pathological aspects of a given organ.
Authors and Affiliations
Lahir YK
Keywords
Related Articles
- EP ID EP754570
- DOI 10.23880/act-16000316
- Views 5
- Downloads 0
QSAR Studies on Some Sulfonamides as Antidiabetic Agents
The need for antidiabetic agents is growing day by day in pharmaceutical industry to find novel, potent and more specialized class of medicine. To address the need we have evaluated a set of sulphonamide drugs for their...
Antioxidant and Tyrosinase Inhibiting Activities of Ethylacetate, Methanolic and Aqueous Extracts of Basella alba Leaves
Basella alba is a leafy green plant commonly cultivated and consumed as vegetable in many Asian and tropical African communities. The plant has been scientifically proven to possess a number of beneficial effects includ...
Effect of 17α-Ethinylestradiol on the Intestinal Calcium Carbonate Excretion Rate of Yellow Fin Sea Bream (Acanthopagrus latus)
Marine fish maintain their hypotonic body fluids by drinking seawater, excreting excess salt, and retaining water. Calcium in seawater is precipitated as CaCO3 in marine fish gut to limit the Ca2+ availability for absorp...
Occupational Cancer, What about Informal Workers in the Agriculture Sector? The Case of Chile
We raise our concern about cancer risks associated with occupational activities performed by Chilean workers in the agriculture sector. It is known that long term occupational exposures to many chemicals and agents (e.g....
Assessment of the Effects of Antiretroviral Medications on Kidney Status in Rwanda
According to the previous research, ART over different durations of time has an effect on the nephron as well as on liver hepatoxicity by inducing toxicity. Renal dysfunction by ART has been associated primarily with ten...