REVIEW ON CASEIN PRODUCTION AND CASEIN BASED NANO-FORMULATIONS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 1
Abstract
Biodegradable systems have the ability to release the drug for a prolonged period of time and subsequently degrade which can be easily cleared from the body. This property makes use of them for the design of carriers for the controlled delivery of therapeutic agents, since it will release the entrapped drug over an extended period of time. Due to its non toxic, biocompatible and slow digesting nature it is an effective matrix in drug delivery. Milk has many proteins, including the nine essential amino acids. The two basic types of proteins in milk are called casein and whey. The ability of casein to modify drug dissolution from compacts was reported. The high tensile strength of casein film, favours its use as an acceptable film-coating for tablets. Casein floating beads were developed to increase the residence time of drugs in the stomach based on its emulsifying and bubble-forming properties. Casein-based microparticles bioactive molecules were prepared via emulsification-chemical cross linking Casein nanoformulations were also prepared to deliver nutraceuticals and synthetic drugs via enzymatic crosslinking, graft copolymerization, heat-gelation and polyelectrolyte ionic complexation. It can be concluded that casein-based formulations are promising materials for controlled drug delivery.
Authors and Affiliations
Neha Arora , Tarun Garg , Ajay Bilandi
Keywords
Related Articles
- EP ID EP145519
- DOI -
- Views 93
- Downloads 0
SIMULTANEOUS ESTIMATION AND VALIDATION OF PARACETAMOL, CHLORPHENIRAMINE MALEATE AND PHENYLEPHRINE HYDROCHLORIDE IN BULK AND TABLET DOSAGE FORM BY USING DIFFERENT SPECTROPHOTOMETRIC METHOD
A simple, precise, accurate and economic simultaneous UV spectrophotometric method has been developed for the estimation of Paracetamol, Chlorpheniramine Maleate and Phenylephrine Hydrochloride in combination in bulk mix...
PHYTOCHEMICAL SCREENING AND THE EVALUATION OF THE ANTIOXIDANT, ANTIMICROBIAL AND ANALGESIC PROPERTIES OF THE PLANT IPOMOEA MAURITANA (FAMILY: CONVOVULACEAE)
Ipomoea mauritiana is an important medicinal plant having widespread application in a variety of disorders. The aim of this study was the phytochemical investigation and evaluation of the anti-oxidant, anti-microbial an...
GOLDEN BENEFITS OF DRINKING KOKAM-COLA
Kokam fruit can be viewed as a wonder berry that has a pleasant, tangy-sweet taste and a myriad of health benefits. This exotic fruit is a native of Sahyadri Mountain range of Western India. Kokam (Garcinia indica), grow...
FORMULATION AND EVALUATION OF INDOMETHACIN MICROSPHERES FOR COLONIC DRUG DELIVERY SYSTEM
Colon specific drug delivery has gained increased importance not just for delivery of drug for the treatment of local diseases, associated with the colon but also potential site for systemic delivery of therapeutic drug....
MOLECULAR MODELING AND DRUG DISCOVERY OF POTENTIAL INHIBITORS FOR ANTICANCER TARGET GENE MELK (MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE)
Maternal embryonic leucine zipper kinase (MELK), a member of the AMP serine/threonine kinase family, exhibits multiple features consistent with the potential utility of this gene as an anticancer target. Reports show tha...