Abstract

The oral delivery system is the mostly preferable route of drug delivery because easy to administered, non-evasive in nature, flexibility in formulation and patient compliance. Gastro retentive drug delivery system (GRDD) improve the bioavailability of drug, therapeutic efficacy and reduce the dosing frequency. Drug absorption in GIT is a high variable procedure and such it depends upon the factors like absorption of drug on site, drug release from the dosage form, gastrointestinaltransit time of dosage forms and gastric emptying process.gastroretentive dosage forms remain in the gastric region for longer periods and prolonged gastric retention time of the drugs. one of the important approach of gastroretentive drug delivery system such as prolong gastric residence time, thereby targeting site specific drug release in the stomach.[4] when mechanism of gastroretentive floating drug delivery system that the formulation are prior to the administered in solution form after the administered solution contact with gastric fluid in stomach they form gel and float on the gastric fluid. The gel are float on gastric fluid in the longer period of time. We have reviewed in this various approaches of gastroretentive drug delivery system, advantages, disadvantages, mechanism of drug delivery and other. Keywords: Gastroretentive Drug Delivery System, Floating system, Non floating system, Microspheres.

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