REVIEW ON TRANSDERMAL DRUG DELIVERY SYSTEM
Journal Title: World Journal of Pharmaceutical and Medical Research - Year 2017, Vol 3, Issue 8
Abstract
Transdermal drug delivery system (TDDS) specialist are ongoing to explore for new method that can efficiently and painlessly transmit better molecules in therapeutic quantity to overcome the Difficulties allied with oral route, namely poor bioavailability due to first pass metabolism and receptiveness to produce rapid blood level. Transdermal drug delivery get improved the therapeutic effectiveness and security of drugs by more site specific way but spatial and temporal placement within body is necessary to reduce both the size and number of doses essential to achieve the objective of systemic medication through topical application to the intact skin surface. Transdermal patches deliver the drugs for systemic effects at a predetermined and controlled rate. Through a diffusion process, the drug enter the bloodstream directly though the skin. Since there is high concentration on the patch and low concentration in the blood, the drug will keep diffusing into the blood, the drug will keep diffusing into the blood for a long period of time, maintain the constant concentration of drug in the blood flow. TDDS is act as micro emulsion, Transdermal patches, Niosomes, Ethosome and liposomal drug delivery system is act as Novel approach of carrier mediated drug delivery system. The success of all the TDDS depends on the skill of the drug to permeate skin in sufficient quantities to achieve its desired therapeutic effect. This review article provides a detailed study of transdermal that is benefit, disadvantages, mechanism, factors affecting skin permeation and types. Characterization of transdermal patch is use to check its quality, size, time of onset & duration, adhesive property, thickness, weight of patch, moisture of content, uniformity & cutaneous toxicological studies.
Authors and Affiliations
Chetan Ghulaxe
Keywords
Related Articles
- EP ID EP657017
- DOI -
- Views 202
- Downloads 0
ANKLE FLEXURE LICHENIFICATION IN THIRTEEN PATIENTS
Lichenification is characterized clinically by thickening of areas of skin in association with exaggerated normal skin markings and hyperpigmentation, it may originates on seemingly normal skin or may develops at the sit...
MUTIFIDUS MUSCLE CROSS SECTIONAL AREA MEASURED BY MRI IN FEMALES WITH CHRONIC IDIOPATHIC NECK PAIN
Multifidus muscles asymmetry and atrophy was found to be associated with chronic idiopathic spine pain[1], OBJECTIVE: This study tries to find a relation between chronic idiopathic neck pain and structural abnormality in...
REVOLUTIONARY EXCELLENCE OF COMPOSITE RESINS - A REVIEW
The introduction of resin-based dental materials around the mid of the last century was a revolution in restorative dentistry. The early formulations were characterized by numerous problems like improper handling charact...
LENGTH OF RESIN TAGS IN SELF ETCHING SEALANT WITH AND WITHOUT PRE ETCHING WITH PHOSPHORIC ACID. AN INVITRO COMPARATIVE STUDY
Background: Caries has been a problem for individuals of all age. The teeth at highest risk for caries are the permanent first and second molars. Pit and fissure dental sealants have reduced caries over 70%. Driven by mo...
UDAVARTHINI YONIVYAPAT AND ITS MANAGEMENT – CONCEPTUAL STUDY
The reproductive process in woman is a complex and highly evolved interaction of many components. Disturbance in any component can cause problems in menstrual cycle; one being is dysmenorrhoea which affects most of the w...