Revitalizing Phage Therapy in Combating Multi-Drug Resistant Bacteria
Journal Title: Haya: The Saudi Journal of Life Sciences - Year 2017, Vol 2, Issue 4
Abstract
Abstract: Bacterial infections are one of the most dangerous infections that threaten the existence and continuity of life. Despite the discovery and manufacturing of effective antibiotics to tackle these menaces, bacteria have developed resistance against such treatments and transformed into new mutant resistant strains. Bacteriophages, or phages, are regarded as effective alternative antibacterial agents. Recently, scientists have been taking a closer look at the variety of different phages that attack bacteria. This review primarily focuses on the potential of phage therapy as an alternative treatment to overcome a wide spectrum of resistant bacterial infections, as well as current phage therapy advancement. It also proposes the idea of engineering “broad-spectrum phage” to overcome a wide range of resistant bacterial infections, and its advantages over antibiotics, individual phage, and phage cocktails. Keywords: Phage therapy, broad-spectrum phage, phage cocktails, bacteriophages, antibiotics, multi-drug resistant bacteria.
Authors and Affiliations
Aida Baharuddin, Amad Abdelkarim El Marghani, Idris Adewale Ahmed, Mohammed Razip Samian
Keywords
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