Rhabdomyolysis in a HIV-infected Patient Following the Addition of Raltegravir, A Case Report with Review of the Literature
Journal Title: Journal of Clinical Research in HIV AIDS and Prevention - Year 2014, Vol 1, Issue 3
Abstract
Antiretrovirals have traditionally been associated with much toxicity. Newer antiretrovirals are considered much less toxic relative to older antiretrovirals. Upon its FDA-approval in 2009, raltegravir’s adverse drug reaction profile was found to be similar to placebo. However, recently there have been reports of increased creatine kinase and rhabdomyolysis following the initiation of raltegravir. We describe a 52-year-old, African-American man who developed rhabdomyolysis after starting raltegravir for HIV. Rhabdomyolysis resolved upon discontinuation of raltegravir. Use of the Naranjo adverse drug reaction probability scale indicated a probable relationship (score of 6). Although raltegravir is a well-tolerated antiretroviral, clinicians should be aware of the possibility of rhabdomyolysis when prescribing this medication.
Authors and Affiliations
Anna L. Johnson, Alexandria Garavaglia Wilson
Keywords
Related Articles
- EP ID EP262748
- DOI 10.14302/issn.2324-7339.jcrhap-13-304
- Views 172
- Downloads 0
Disability and Health Outcomes – From a Cohort of People on Long Term ART
HIV and AIDS remains a major health problem in South Africa even after two decades since the introduction of antiretroviral therapy. Long term survival with HIV is associated with new health related issues and a risk of...
Undergraduate Student’s Perception of HIV/AIDS.A Case of Obafemi Awolowo University Ile-Ife, NIGERIA
Perception of Human Immunodeficiency Virus has been topical due to its central place in determining attitudes and care for people living with HIV/AIDS and having implications for the containment of the epidemic. People l...
Sport Activities as a Vehicle for HIV/ AIDS Prevention in Trinidad and Tobago: Organizer’s Perspectives
Various sporting activities are being used as vehicles for HIV/AIDS education and prevention within the field of sport-for-development (SFD). Kicking AIDS Out! is one SFD program that aims to promote protective attitudes...
Recognizing the Costs of Teen Pregnancy: “Baby Think it Over”
Despite recent improvements in teen pregnancy and birth rates, 2000 teens get pregnant each day in the U.S. Innovative strategies that are effective and acceptable within communities are needed to continue these declines...
Clinical and Immunological Beneficial Effects of Phyto V7 Consumption by HIV-1 Seropositive Individuals
Phytochemicals (PHT) are a large group of biologically active plant chemicals that may have positive effects on human health such as immune system stimulation, down regulation of inflammatory responses, radical scavengin...