Ribavirin priming has no beneficiale effects for chronic hepatitis C patients
Journal Title: Przegląd Epidemiologiczny - Year 2014, Vol 68, Issue 3
Abstract
AIM. The aim of this study is to assess the efficacy of an initial dose of ribavirin administered before a 48-week course of treatment with peg-IFN + ribavirin in treatment-naïve patients and in patients after previous failure of CHC treatment. MATERIAL AND METHODS. A total of 103 patients with chronic hepatitis C infected with genotype 1 HCV were qualified to the study. Study patients were randomised to receive one of two treatments: A- RBV for 4 weeks followed by combined therapy with peg-IFN alpha-2a +RBV for 48 weeks (n = 73), or B- combined therapy with peg-IFN alpha-2a +RBV for 48 weeks (n = 30). RESULTS. SVR 24 was observed in 44% patients in group A and in group 40% patients in group B (40%), p > 0.05. Comparing subgroups of the naive patients, it was found that the SVR24 value was higher in group A than group B (57% vs. 47%, p > 0.05). In the re-therapy subgroups, higher treatment response rates in patients not responding earlier was found in group A than group B (39% vs. 16%, p > 0.05). CONCLUSION. No significant advantage was found in the use of a priming method over a standard regimen. However, it could be recommended in patients with a total lack of response to peg-IFN and ribavirin when no other therapeutic options are available.
Authors and Affiliations
Anna Piekarska, Kamila Wójcik, Małgorzata Sidorkiewicz, Zbigniew Deroń, Elżbieta Jabłonowska
Keywords
Related Articles
- EP ID EP72705
- DOI -
- Views 90
- Downloads 0
Incidence of healthcare-associated gastroenteritis in children hospitalized on paediatric ward in provincial hospital in 2007-2013
OBJECTIVE. This article aimed at evaluating the incidence and distribution of healthcare-associated (HAI) gastroenteritis (GE) in patients hospitalized on paediatric ward in St. Lukas Provincial Hospital in Tarnów. INTRO...
High prostate cancer mortality in Poland. A spatial, temporal and structural analysis / Wysoka umieralność na nowotwory gruczołu krokowego w Polsce. Analiza przestrzenna, czasowa i strukturalna
INTRODUCTION: This study investigates spatial distribution and future trends in prostate cancer mortality in Poland. Since detection of prostate cancer is based on patients’ requests (not an invitation system), hypothesi...
Epidemiological characteristics of patients with syphilis in Gdańsk and Warsaw in 2016 / Charakterystyka epidemiologiczna chorych na kiłę w Gdańsku i w Warszawie w 2016 roku
INTRODUCTION: Syphilis is a systemic disease with a complex natural history and a diversified clinical symptomology, taking various forms. It is characterized by a long-term course, often asymptomatic. The Global Estimat...
Rapid appraisal of road-safety environment around educational institutions of Mangaluru city, South India
INTRODUCTION: Road traffic accidents (RTA) are the biggest killers according to the Global Status Report on Road Safety. OBJECTIVE: The objective of the present study was to assess the road safety in the vicinity of the...
Usefulness of SOFA score and artesunate - based treatment in severe malaria – a single center study / Użyteczność skali SOFA oraz terapii opartej na artesunacie w ciężkiej malarii – badanie jednoośrodkowe
INTRODUCTION: This study was conducted to assess the usefulness of the guidelines of treatment recommended in Malaria diagnosis and treatment guideline published by University College London Hospitals-NHS Foundation Trus...