Risk Assessment of Co-treatment with Tenofovir and Rifampicin on Kidney Oxidative Stress Markers of Male Albino Rats
Journal Title: International Journal of Contemporary Medical Research - Year 2016, Vol 3, Issue 1
Abstract
Introduction: Rifampicin (RIF) and tenofovir (TDF) may be associated with oxidative kidney damage; hence co-therapy with tenofovir-rifampicin in human immunodeficiency virus and tuberculosis co-infection may be characterized by synergistic oxidative kidney damage. This study, therefore evaluated the toxicological effect of co-treatment with tenofovir-rifampicin on kidney oxidative stress markers of male albino rats. Materials and Methods: Adult male rats used for this study were divided into five groups A-E of sixteen animals (16) each. Animals in group A (placebo control) were orally treated with water, while animals in group B (solvent control) were orally treated with arachis oil. Animals in groups C-D were orally treated with 80 mg/kg of rifampicin, 32 mg/kg of tenofovir and tenofovir-rifampicin for 1-8 weeks respectively. At the end of drug therapy animals were sacrificed kidney collected and analyzed for superoxide dismutase, catalase, glutathione, glutathione-s-transferase, and malondialdehyde. Results: Co-treatment with tenofovir-rifampicin insignificantly (p>0.05) decreased superoxide dismutase, catalase, glutathione, and glutathione-s-transferase levels with increase in malondialdehyde level when compared to treatments using individual doses of rifampicin and tenofovir. Conclusion: This study shows co-therapy with tenofovir-rifampicin may not be associated with synergistic oxidative kidney damage.
Authors and Affiliations
Elias Adikwu, Igbans Rejoice Obele, Odoko J. Onyedenyifa, Apiakase Williams Ebipade
Keywords
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