Risk factors analysis of severe refractory Mycoplasma pneumoniae pneumonia complicated with bronchitis obliterans in children
Journal Title: Journal of Clinical Pediatrics - Year 2025, Vol 43, Issue 1
Abstract
[Objective ] To explore the independent risk factors of severe refractory Mycoplasma pneumoniae pneumonia (SRMPP) complicated with bronchitis obliterans in children. [Methods ] The clinical data of children with SRMPP admitted to the Department of Pediatrics from October 2021 to October 2023 were retrospectively analyzed. All patients were divided into two groups: one group had the sequelae of bronchitis obliterans (occluded group) and the other group had not bronchitis obliterans (non-occluded group), and the differences in clinical characteristics between the two groups were compared. Multivariate logistic regression was used to analyze the independent risk factors of SRMPP complicated with bronchiolitis obliterans, and receiver operating characteristic (ROC) curve was used to analyze the predictive value of each factor for SRMPP complicated with bronchiolitis obliterans. [Results ] A total of 110 SRMPP children (60 boys and 50 girls) with a median age of 6.0 (4.0-8.0) years were included, 40 of whom were complicated with obliterated bronchitis. Multivariate logistic regression analysis showed that increased D-dimer level and plastic mucus plugs were independent risk factors for SRMPP complicated with bronchiolitis obliterans (P<0.05), while high levels of prealbumin were independent protective factor (P<0.05). ROC curve analysis showed that the areas under the ROC curve (AUC) of D-dimer increase, prealbumin decrease and plastic mucus plugs in predicting SRMPP complicated with bronchitis obliterans were 0.69, 0.74 and 0.70, respectively. [Conclusions ] For SRMPP children with serum prealbumin level≤13.2 mg/dL,plasma D-dimer level≥1.85 mg/L, and plastic mucus plug formation, it is necessary to be alert to the occurrence of bronchitis obliterans.
Authors and Affiliations
Dongxia LIU, Rong JIN, Rongjun LIN
Keywords
Related Articles
- EP ID EP759994
- DOI 10.12372/jcp.2025.24e0129
- Views 26
- Downloads 0
Clinical analysis of 153 neonatal enterovirus infections and antibiotic management improvement study
[Objective] To analyze the clinical features of neonatal enterovirus infection and to explore the effect of antibiotic management improvement on reducing the use of antibiotics in children with enterovirus infection. [Me...
Clinical phenotype and genotype analysis of 24 epileptic children with KCNQ2 gene variation
[Objective] To investigate the clinical and genetic characteristics of children with epilepsy caused by variations of the KCNQ2 gene (OMIM #602235). [Methods] The clinical data of 24 children with KCNQ2 gene variants (NM...
Exploring the feasibility of enzyme activity assay of dried blood spots for newborn screening of mucopolysaccharidosis type Ⅱ
[Objective] To explore the feasibility of detecting iduronate 2-sulfatase (IDS) activity in dried blood spot (DBS) for screening of mucopolysaccharidosis type Ⅱ (MPS Ⅱ) in newborns. [Methods] The IDS activity of DBS was...
The effect of vegetarian diet on children and adolescents
Vegetarian diets have become increasingly popular due to their perceived health benefits, with the majority of research focusing on the nutritional status and disease implications in adults. However, less attention has b...
Clinical progress in prevention and treatment of early parenteral nutrition-related "refeeding syndrome" in high-risk newborns
Refeeding syndrome is a metabolic disorder characterized by electrolyte disorder, mainly low phosphorus, low potassium and low magnesium, and its clinical manifestations are non-specific and diverse. It is common in maln...