Risk Factors and Neurologic Outcomes in Childhood Arterial Ischemic Stroke

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Risk Factors and Neurologic Outcomes in Childhood Arterial Ischemic Stroke

Journal Title: JOURNAL OF CONTEMPORARY MEDICINE - Year 2017, Vol 7, Issue 3

Abstract

Objective: The aim of this study is to describe clinical characteristics, treatment modalities and outcomes of children with arterial ischemic stroke (AIS). Material and Methods: We retrospectively reviewed the charts of 102 children (62 girls and 40 boys) with AIS admitted at our hospital between 2009 and 2015. Age at stroke, sex, medical history, family history, clinical findings upon admission, history of seizure, and radiological findings were recorded. Cardiac assessment, hematological and immunological tests, metabolic screening were all performed in the patients. Results: In 25 children stroke occured as a complication of cardiac disease, 12 had transient cerebral arteriopathy, 11 had Down’s syndrome, 9 had thalassemia, 7 had moyamoya disease, 6 had MTHFR mutation, 4 had homozygote for factor V Leiden, 3 had protein C deficiency, 1 had sickle cell disease, and in 24 children no underlying cause could be found. Multiple risk factors were found in 16 children and recurrent stroke was observed in 4 patients. Hemiplegia was the commonest initial clinical presentation (88.2%) followed by seizure (66.6%) and decreased level of consciousness (54.9%). The avarage length of follow-up was 32.1±5.4 months. The outcome in all 102 stroke patients was as follows: asymptomatic 57.8%; persistent neurologic deficit or epilepsy 40.2%; and death 2%. Conclusion: Our study showed an underlying cause for AIS in 76.5% of the patients; 42.2% of the patients either died or had motor and/or cognitive sequelae and recurrence occured despite prophylactic aspirin treatment in 4 patients.

Authors and Affiliations

Taner Sezer

Keywords

Arterial Ischemic Stroke children

EP ID EP423326
DOI 10.16899/gopctd.349950
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