Risk factors for degenerative aortic valve disease in India: A case control study
Journal Title: Medical Journal Armed Forces - Year 2018, Vol 74, Issue 1
Abstract
Background: Degenerative aortic valve disease often co-exists with coronary artery disease (CAD) and studies done in western populations have shown that it shares the same risk factors which cause CAD. However little is known in this context among Asian Indians. The current study looks into the risk factors of degenerative aortic valve disease in Asian Indian population. Methods: Ninety-one consecutive patients with severe aortic stenosis (AS) reporting for left heart catheterization prior to valve replacement surgery at a tertiary care centre were recruited for the study. They were compared with age and sex matched controls selected from a database of 3200 patients referred for elective diagnostic left heart catheterization for suspected CAD. Following traditional cardiovascular risk factors were assessed in all patients: age, gender, family history of CAD, smoking history, presence of diabetes, hypertension and dyslipidemia. Results: The mean age of the study population was 57.8 8.2 years (range, 40–80 years). Smoking, family history of CAD and hypercholesterolemia were significantly more prevalent in patients with degenerative AS compared to those with normal valves. No significant difference was noted in the presence of diabetes mellitus. On multivariate logistic regression, family history of premature CAD (OR 3.68; CI 1.38–9.78) smoking history (OR, 2.56; CI, 1.21–5.39), and raised LDL levels (OR, 5.55; CI, 2.63–11.69) were independently associated with the aortic stenosis patient cohort. Conclusions: The study showed a significant association of cardiovascular risk factors with aortic stenosis independent of age and gender in Asian Indian patients.
Authors and Affiliations
D. S. Chadha
Keywords
Related Articles
- EP ID EP639979
- DOI 10.1016/j.mjafi.2017.03.004
- Views 73
- Downloads 0
Gender differential and implications in the epidemiology of stress fractures among cadets of Indian Armed Forces
Background: Most studies on stress fractures in India have been carried out among recruits as against officer trainees and limited to males. With the continuous induction of women in the Armed Forces, it was decided to c...
Managing a case of crowding with associated severe periodontitis
The etiology of crowding is the disproportion between tooth material and jaw size. It may be either due to increased mesiodistal widths of teeth or smaller jaws or their combination. Whenever there is insufficient space...
Bibliometric Indices of Scientific Journals: Time to overcome the obsession and think beyond the Impact Factor
Journal Impact Factor (JIF) has been widely used for a long time as a proxy marker of journal prestige. However, off late, accuracy and reliability of JIF for evaluation of scientific journals has been increasingly quest...
Determinants of injuries and Road Traffic Accidents amongst service personnel in a large Defence station
Background: Injuries are assuming epidemic proportions globally; and in India. Also, previous decade witnessed carnage on Indian roads, with nearly 12 lakh people killed and 55 lakhs disabled in road crashes. The trend i...
Hydrogen peroxide test for intraoperative bile leak detection
Background: Bile leakage (BL) is a common complication following liver surgery, ranging from 3 to 27% in different series. To reduce the incidence of post-operative BL various BL tests have been applied since ages, but n...