Risk factors for hearing loss in neonates
Journal Title: Paediatrica Indonesiana - Year 2015, Vol 55, Issue 6
Abstract
Background An estimated 6 of 1,000 children with live births suffer from permanent hearing loss at birth or the neonatal period. At least 90% of cases occur in developing countries. Hearing loss should be diagnosed as early as possible so that intervention can be done before the age of 6 months. Objective To determine risk factors for hearing loss in neonates. Methods We performed a case-control study involving 100 neonates with and without hearing loss who were born at Sanglah Hospital, Denpasar from November 2012 to February 2013. Subjects were consisted of 2 groups, those with hearing loss (case group of 50 subjects) and without hearing loss (control group of 50 subjects). The groups were matched for gender and birth weight. We assessed the following risk factors for hearing loss: severe neonatal asphyxia, hyperbilirubinemia, meningitis, history of aminoglycoside therapy, and mechanical ventilation by Chi-square analysis. The results were presented as odds ratio and its corresponding 95% confidence intervals. Results Seventy percent of neonates with hearing loss had history of aminoglycoside therapy. Multivariable analysis revealed that aminoglycoside therapy of 14 days or more was a significant risk factor for hearing loss (OR 2.7; 95%CI 1.1 to 6.8; P=0.040). There were no statistically significant associations between hearing loss and severe asphyxia, hyperbilirubinemia, meningitis, or mechanical ventilation. Conclusion Aminoglycoside therapy for >=14 days was identified as a risk factor for hearing loss in neonates.
Authors and Affiliations
Ni Luh Maharani, Ekawaty Haksari, I Wayan Artana
Keywords
Related Articles
- EP ID EP448577
- DOI 10.14238/pi55.6.2015.328-32
- Views 84
- Downloads 0
Risk factors of childhood leukemia
Background The incidence of childhood leukemia has increasedannually. Recent studies have shown that childhood leukemia isinitiated in utero, and have focused on prenatal risk factors suchas birth weight and parental age...
PELOD score, serum procalcitonin, and lactate levels in pediatric sepsis
Background Sepsis remains a major cause of morbidity and mortality among critically ill children in the pediatric intensive care unit (PICU). Procalcitonin and lactate have been used as biomarkers of sepsis, as they have...
Persistent proteinuria as an indicator of renal disease in HIV-infected children
Background Persistent proteinuria (microalbuminuria) has been reported to be a precursor of HIV-related renal disease. Screening allows for early management in order to prevent the progression of renal disease and decrea...
Utility of hemoglobin A1c to screen for impaired glucose tolerance
Background Childhood obesity is associated with an increasedlikelihood for having impaired glucose tolerance, dyslipidemia,and diabetes. Hemoglobin Ale (HbAl c) h as emerged as arecommended diagnostic tool for identifyin...
Mantoux test results and BCG vaccination status in TB-exposed children
Background Tuberculosis (TB) infection is highly prevalent in Indonesia. The source of transmission of TB to a child is usually via an adult with sputum smear-positive pulmonary tuberculosis. The Mantoux test is a diagno...