ROLE OF 400 MCG INTRAOPERATIVE SUBLINGUAL MISOPROSTOL FOR REDUCTION OF CAESAREAN BLOOD LOSS
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2017, Vol 4, Issue 10
Abstract
BACKGROUND Lower segment caesarean section is a common surgical procedure. Postpartum haemorrhage incidence after LSCS is 4%. Misoprostol is a prostaglandin E1 analogue with good uterotonic properties, easy availability, low cost, thermostability, long shelf life, easy administration and few adverse effects at therapeutic dose. It is readily absorbed by oral, sublingual, buccal, vaginal or rectal route. Sublingual route attains quickest concentration. Dose of 400 mcg was chosen in this study to minimise adverse effects with optimal therapeutic benefit. The aim of the study is to determine the efficacy of sublingual misoprostol in reducing caesarean blood loss. MATERIALS AND METHODS It is a prospective experimental study done in VSSIMSAR, Burla. Women undergoing LSCS were randomly assigned to study and control groups of equal strength of 100 each. In all cases, preoperative Hb%, haematocrit, pulse, BP was noted. Study group were given 400 mcg misoprostol at the time of cord clamping. In control group, nothing was given. In all patients, active management of third stage of labour was done by using oxytocin 10 IU (IV) along with uterine massage. Blood loss soaked by tetra was calculated using formula, blood loss = wet weight-dry weight/1.05 (1.05 is constant). Amount of blood loss, postoperative Hb%, haematocrit, pulse rate, BP was noted in both groups and compared. BP and pulse were noted after 1 hour and Hb%, haematocrit were noted after 24 hours. RESULTS Study group showed significant decrease in total blood loss (around 117.9 mL) as compared to control group. There was significant decrease in the postoperative fall in Hb in the study group as compared to control, the mean difference being 0.631 gm%. Study group also showed decrease in postoperative fall in haematocrit as compared to control, the mean difference being 0.055. CONCLUSION Misoprostol significantly reduced caesarean blood loss and doesn’t affect foetal outcome without significant adverse effect.
Authors and Affiliations
Lalmohan Nayak, Kumudini Pradhan, Satyjeet Mishra
Keywords
Related Articles
- EP ID EP213752
- DOI 10.18410/jebmh/2017/112
- Views 105
- Downloads 0
SOCIODEMOGRAPHIC PROFILE AND TYPE OF HEARING LOSS IN CSOM FROM A TERTIARY CARE HOSPITAL FROM A RURAL AREA
INTRODUCTION CSOM is a prevalent infection in children. Commonly cause by micro-organism like bacteria fungi or virus It can cause mild to moderate hearing loss. AIMS AND OBJECTIVE To find out the socio-demographic statu...
TWO DIFFERENT DOSES OF DEXMEDETOMIDINE IN ATTENUATING SYMPATHOADRENAL RESPONSE TO ENDOTRACHEAL INTUBATION - A COMPARATIVE STUDY
BACKGROUND The objective of our study was to determine whether a lower dose (0.6 microgram/kg) of dexmedetomidine is as effective as the usual dose (1 microgram/kg) for attenuating sympathoadrenal response to endotrachea...
VARIANT ANATOMY OF THE PULMONARY VENOUS ORIFICES AND THEIR CLINICAL SIGNIFICANCE
Interest in the study of pulmonary veins and its ostia has considerably increased in recent times after the realization of the fact that atrial fibrillation may originate from the triggers in the pulmonary veins as they...
AGGRESSIVE PERIOSTEAL NONHODGKIN’S LYMPHOMA IN A 3 YEARS OLD BOY
Non-Hodgkin’s disease is a type of lymphoma and accounts for approximately 1% of all cancers. [1] It spreads contiguously and along lymphatic pathways. Non-Hodgkin’s disease is usually confined to the lymph nodes, althou...
AUDIOLOGICAL EVALUATION IN GERIATRIC AGE GROUP
INTRODUCTION: Age Related Hearing Loss (ARHL) is defined as loss of hearing in elderly persons not influenced by the extraneous factors like noise trauma etc or intrinsic like CVS related diseases or endocrinal disorders...