Role of ada and cytology in the diagnosis of Exudative pleural effusion
Journal Title: INTERNATIONAL JOURNAL OF CURRENT RESEARCH - Year 2016, Vol 8, Issue 8
Abstract
Background: Exudative pleural effusions are a common diagnostic problem in clinical practice and it is difficult to determine the cause of pleural effusion. Aims and objectives: to evaluate the role of ADA and cytology in diagnosis of exudative plural effusion Materials and methods: 100 patients with exudative plural effusions were recruited Results: Tuberculosis was the most common cause of plural effusion in 74% followed by malignancy 18% then synpneumonic 6%. majority of tubercular pleural effusions 86.47% were found in less than 50 years of age and majority of malignant pleural effusion found in more than 50 years of age (73.03%). 89.18 % and 84.62% are the sensitivity and specificity of the test if ADA 40 U/L cutoff is used for finding extra pulmonary TB, it is 67.5% and 100% when the ADA 63U/L cutoff is used and it is 83.78% and 96.15% when ADA and cytology both included. Conclusion: In a clinically suspected case of plural effusion if the plural fluid ADA is >63U/L, it is virtually diagnostic of tubercular pleural effusion. If ADA is in between 40-63U/L it is highly suspicious of tubercular pleural effusion, and then the cytology report will aid in confirming the diagnosis.
Authors and Affiliations
Sunil Kumar, Anil Saxena, Suman Khangarot, Anees K. V. and Kamal Nayan
Keywords
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