Role of alpha tocopherol as an adjuvant therapy in pregnancy induced hypertension
Journal Title: Pakistan Journal of Pharmacology - Year 2011, Vol 28, Issue 2
Abstract
Hypertension is the most common medical problem encountered in pregnancy and remains an important cause of maternal and fetal morbidity and mortality. To conduct a clinical study to evaluate the adjuvant effect of alpha-tocopherol along with routine hypertensive measures in patients with pregnancy induced hypertension. A total of 25 pregnancy induced hypertensive patients with single fetus were prospectively followed up from 24 to 28 weeks of pregnancy till the end of pregnancy. The patients were given capsule alpha-tocopherol 400mg/day as adjuvant therapy. The base line readings and then at 4 weekly intervals of maternal blood pressure and platelets count and evaluated statistically till the end of pregnancy. The mean systolic blood pressure and diastolic blood pressure decreased by 3.5% and 4.36% respectively with significant p value <0.01. The platelet count increased by 5.98% though statistically non significant. Maternal blood pressure decreased and platelet count increased by oral supplementation of alpha tocopherol. Therefore the effect of alpha-tocopherol on these parameters should be considered in future for longer duration and larger scale studies.
Authors and Affiliations
Shamama Bashir, Syed Hasan, Shaikh Ahmed, Touba Basar
Keywords
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