Role of Amoxicillin, Azithromycin and Moxifloxacin in the empirical treatment of community acquired bacterial sinusitis – An open label randomized study
Journal Title: INTERNATIONAL JOURNAL OF RECENT TRENDS IN SCIENCE AND TECHNOLOGY - Year 2016, Vol 20, Issue 2
Abstract
Background: The study was conducted to compare the safety and efficacy of Amoxicillin, Azithromycin and Moxifloxacin in the empirical treatment of acute bacterial sinusitis. Materials: Inthis open label randomized study, Sixty patients of both sexes in the age group of 18 to 65 years showing clinical and radiological evidence of acute bacterial sinusitis were randomly allocated to three groups namely Group 1 receivedamoxicillin 500 mg three times a day for 7 days, group 2 received azithromycin 500 mg OD for 3 days while the third group received moxifloxacin 400 mg OD for 7 days. The patients were followed to look for signs of clinical improvement, to repeat the investigations and for any drug induced adverse reactions. Results: Data of 50 patients who completed the study including 16 patients in Group 1 and 2, 18 patients in group 3 was analyzed. Overall symptomatic improvement was almost similar, 81.25% with amoxicillin, 82.50% with azithromycin and 88.46% with moxifloxacin. The clinical cure rate with azithromycin was 75% compared to 77.7 % with moxifloxacin and 68.75% with amoxicillin. Physical signs of acute sinusitis evidenced by rhinoscopy improved better with azithromycin (66.66%) than amoxicillin (50%) and moxifloxacin (55.55%). Significant reduction in Neutrophil count was seen with all the three drugs. The improvement in radiological appearance was slightly lower with amoxicillin. Adverse effects reported were mild and subsided after treatment. Conclusion: The clinical cure of acute sinusitis is high with moxifloxacin but compliance would be much better with azithromycin because of its three day course.
Authors and Affiliations
V Padmavathi, Kranti T
Keywords
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