ROLE OF ANTI-HELICOBACTER PYLORI THERAPY IN IRON DEFICIENCY ANAEMIA- A PROSPECTIVE STUDY
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2017, Vol 6, Issue 81
Abstract
BACKGROUND Accumulating evidence suggests that Helicobacter pylori (H. Pylori) infection account for many unexplained cases of Iron Deficiency Anaemia (IDA), which may benefit from testing and treatment for H. pylori infection. This study attempts to evaluate the role of anti H. pylori treatment in management of iron deficiency anaemia among patients treated at a tertiary care centre in North India. MATERIALS AND METHODS This was a prospective study which included 60 patients with IDA, proven positive for H. pylori by Rapid urease test and histopathological staining. They were divided into three groups (n= 20) and received different treatments, i.e. only anti-H. pylori therapy/ oral iron therapy plus anti-H. pylori therapy/ only oral iron therapy. Haemoglobin, RBC indices, Reti count, S. iron and S. ferritin were compared at the end of treatment with One-Way ANOVA. RESULTS At the end of our study, we observed that there is significant increase in Hb in patients treated with anti-H. pylori therapy single or in combination compared to patients only on oral iron therapy (p < 0.001). Maximum improvement in Hb was observed in treatment group receiving both oral iron and anti-H. pylori treatment and it was significant compared to other two groups (p < 0.001). CONCLUSION This study is definitely suggesting significant role of chronic H. pylori gastritis as a cause of refractory IDA. Therefore, we suggest in all cases of refractory or chronic IDA patient must be investigated for the presence of H. pylori gastritis.
Authors and Affiliations
Abdul Shahid Poovathum Parambil, Shaiji Panthiyil Shahulhameed
Keywords
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- EP ID EP275344
- DOI 10.14260/jemds/2017/1235
- Views 69
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