Role of Ascorbic Acid in Male Fertility and its Relation with Free Testosterone
Journal Title: International Journal of Contemporary Medical Research - Year 2017, Vol 4, Issue 6
Abstract
Introduction: Ascorbic acid is present at approximately ten fold higher concentration in seminal plasma as compared to blood and is mostly secreted from seminal vesicles. The present study aimed to assess the influence of seminal plasma ascorbic acid on seminogram characteristics and to assess the effect of endogenous testosterone on the seminal levels of ascorbic acid. Material and Methods: Routine seminogram parameters were analysed from the semen samples obtained from150 male partners of infertile couples of age 21-50 who attended the Reproductive Biology Unit of the department of Physiology. Subjects were classified into two main groups. Group A-the subjects with normal ejaculates and group B-the subjects with abnormal ejaculates. These two groups were further subdivided into the following groups: i) Asthenoteratozoospermics (n=43); ii) Oligoasthenoteratozoospermics (n=24); and iii) Azoospermics (n=21). The seminal plasma ascorbic acid was measured spectrophotometrically and sample for serum free testosterone was sent to Thyrocare laboratory. Results: We found that the seminal plasma ascorbic acid was significantly lower in the abnormal ejaculates than in the normal ejaculates. It was observed that there is statistically significant positive correlation between the seminal plasma ascorbic acid and levels of free testosterone in serum (p<0.05, r=0.279). Statistically significant correlation was also found between seminal plasma ascorbic acid and all parameters of seminogram like sperm concentration, sperm motility and sperm morphology (p<0.05, r= 0.77, 0.85 and 0.83 respectively). Conclusion: The significant causative factor in impairing sperm functions may be the low levels of seminal plasma and its dependence on endogenous free testosterone is observed from a positive correlation between the two.
Authors and Affiliations
Radhika Kothari, Satish Waghmare, A. R. Choudhari
Keywords
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