Role of Aspirin in Patients with Bladder Cancer Receiving Intravesical Bacillus Calmette-Guerin: A Prospective, Observational Study
Journal Title: Journal of Clinical and Diagnostic Research - Year 2017, Vol 11, Issue 10
Abstract
Introduction: High-Risk Non-Muscle Invasive Bladder Cancers (HR NMIBC) are prone to recur and progress even with intravesical Bacillus Calmette-Guerin (BCG) therapy. Aim: To investigate the role of aspirin in prevention of early recurrence and progression in patients with HR NMIBC receiving intravesical BCG. Materials and Methods: This was a prospective, single centre, observational study that included patients with HR NMIBC {Ta, T1 or Carcinoma in situ (CIS)} from February 2015 to January 2017. Patients were screened for eligibility based on clinical, radiological and risk factor profile assessment, history of treatment with aspirin and medical records. Eligible patients were grouped into Group 1 and Group 2 based on aspirin (for minimum of three months) or non-aspirin consumption respectively. Both groups received similar induction, maintenance and intravesical BCG therapy; according to Southwest Oncology Group (SWOG) protocol. Follow up cystoscopy was done every three months for up to two years. Results: A total of 152 patients were screened and 103 patients were included in the study (Group 1, n=15; Group 2, n=88). Binary progression analysis revealed that focality was the only significant predictor variable for the recurrence (OR, 5.064; p=0.001). Aspirin intake was not related to stage (p=0.595), grade (p=0.558), recurrence (p=0.508) and progression (p=0.621) of the tumour. Kaplan-Meier analysis showed that 12-month recurrence (64.2% versus 64.7%, p=0.566) and progression free survival rate (66.7% versus 57.3%, p=0.640) were same in both groups. Conclusion: Results showed that aspirin does not affect the recurrence and progression of HR NMIBC in patients receiving BCG therapy.
Authors and Affiliations
Rupesh Gupta, Ranjit Kumar Das, Sweta Gupta, Arpan Choudhary, Supriya Basu, Parthav P Deb, Ranjan K Dey
Keywords
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- EP ID EP364871
- DOI 10.7860/JCDR/2017/31588.10690
- Views 47
- Downloads 0
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