Role of Autologous Platelet Derived Growth Factor and Fibrin Rich Plasma in Management of Chronic Non-healing Ulcer–A Pilot Study
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2016, Vol 12, Issue 12
Abstract
Background and Objectives: Chronic non-healing ulcer (CNHU) develops due to infections, trauma or underlying any medical and surgical conditions. Ulcer that have failed to response all available mode of treatment for long duration are more likely to develop gangrene and infection prone to limb amputation. This is a major public health problem. None of the conventional treatments are anticipated to stimulate active wound healing. The objectives of this study is to test the efficacy of topically applied autologous platelet derived growth factors and fibrin rich plasma in active repair of chronic non healing ulcer. Methods: Patients having one or more ulcers who have been receiving conventional treatment for their at least for more than 6 months duration but showed no evidence of healing till date were included in this study. Total of 30 skin ulcers were registered, of which 15 patients did not return for follow up. Rest 15 patients were included as the study group. All ulcers were treated with autologous platelet derived growth factors and fibrin rich plasma enriched antibiotic ointment. We observed that 73.33% ulcers were complete healed & rest ulcers had signs of improvement. Results: The study group showed complete healing in 73.33% ulcers and average 80% improvement observed in each ulcer, after applying autologous platelet derived growth factors and fibrin rich plasma. Significant ulcer healing was observed in patients who were less than 40 years of age, had no history of addiction for any toxic substance, and had ulcer size less than 30 sq cm. Ulcer healing rate was also found to be higher in cases whose duration of ulcer was within one year and those who did not have any history of systemic diseases. Conclusion: This study clearly shows the efficacy of topically applied autologous platelet derived growth factors and fibrin rich plasma in management of chronic non-healing ulcer.
Authors and Affiliations
Suprava Patel, Piyush Bhargava, V. Jain, O. P. Tucker, P. K. Khodiar
Keywords
Related Articles
- EP ID EP340528
- DOI 10.9734/BJMMR/2016/22635
- Views 79
- Downloads 0
Moderately Increased Albuminuria; Marker of Chronic Complications in Nigerian Diabetes Mellitus Type 2 Patients; Makurdi Perspective
Background: Diabetes mellitus (DM) and its complications are on the increase especially in the developing countries with significant negative economic consequences on individuals, families and health systems. Objective:...
Non-invasive Assessment of the Severity of Aortic Stenosis by Doppler Derived Aortic Valve Coefficient: A Retrospective Feasibility Study in Humans
Background: Accurate assessment of the severity of stenosis is critical in patients with aortic stenosis. The ambiguities and imprecisions of the current diagnostic parameters can result in sub-optimal clinical decisions...
A Case of Chronic Aortic Dissection with Medial Calcification
Aims: Cystic medial necrosis is the most common pathological change of dissection. Medial calcification is mainly recognized in peripheral arteries and arterioles, but it can occur in the aorta. We, herein, report a case...
The Ethics of Facial Plastic Surgery
In a modern world of aesthesis, the role of surgery is ever broadening and with this healthcare professionals must be in constant vigilance of ethical values. We discuss the role of facial plastic surgery in modern socie...
Chronic Oral Alendronate Use is Associated with Gastrointestinal Reflux Disease and Voice Alterations Irrespective of the Presence of Esophagitis
Aims: This study aimed to compare the presence of atypical symptoms and signs of gastroesophageal reflux disease (GERD) in postmenopausal women with osteoporosis on long-term oral alendronate (ALN). Methodology: One hund...