Role of beta-2 microglobulin in renal dysfunction of Neonates with Birth Asphyxia
Journal Title: Pediatric Review: International Journal of Pediatric Research - Year 2016, Vol 3, Issue 1
Abstract
Objective: study was conducted to assess role of beta-2 microglobulin in renal dysfunction of Neonates with Birth Asphyxia. Methods: Study is a Case control studyand a total of 140 babies were selected for study group as cases of birth asphyxia and 70 normal term babies were selected as control group randomly. Urine samples were taken on day 1, 3 and day 7 in all the babies and beta 2 microglobulin (B2M) values were estimated in all the babies by ELISA method from urine samples. Results: The mean value of beta 2 microglobulin ( B2M) in neonates with birth asphyxia were 10.53 + 6.03, 8.25 + 3.56, 6.25 + 2.72 mg / L and in neonates of control group were 1.61 + 1.01, 1.51 + 1.04 and 1.54 + 1.03 mg / L on day 1, 3 and 7. The p-value for these two groups was < 0.001, which is highly significant. Conclusion: beta 2 microglobulin (B2M) is a sensitive indicator for renal dysfunction. It can even detect subclinical renal impairments in neonates with birth asphyxia which are usually missed by standard renal function tests. It can also be used as early marker or screening test for renal impairments.
Authors and Affiliations
Ghanshyam Chaudhary, Vidya Chaudhary, Sunil Dagar, Arvind Singh
Keywords
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