Role of Bone Marrow Aspiration and Biopsy in Diagnosis of Hematological Disorders: A Prospective Study
Journal Title: Journal of Pharmaceutical and Biomedical Sciences - Year 2011, Vol 6, Issue 3
Abstract
Background The use of bone marrow biopsy as a diagnostic procedure is being increasingly used in recent years. In the present study, an attempt has been made to find out the diagnostic utility of bone marrow aspiration and biopsy with their comparative study. The objective of this study is to correlate the bone marrow aspiration and biopsy findings. Materials and Methods This study was hospital-based prospective study in which 35 consecutive patients with haematological disorders were evaluated by both bone marrow aspiration and biopsy. The results were compared with that of previously published literature. Results Out of 35 cases, maximum number of cases were of acute leukemias 12 (34.28%) followed by lymphoprotiferatide disorders 7 (25%), and one case (2.86%) of myelodysplastic syndrome. Bone marrow aspiration resulted in dry tap in 4 (11.42%) cases, which was observed in aplastic anaemia, myelodysplastic syndrome, primary myelofibrosis and NHL, one case in each. Conclusions Bone marrow biopsy is more reliable in assessing cellularity, bone marrow architectural pattern, distribution and fibrosis. Bone marrow biopsy is diagnostic investigation in ‘dry tap’ aspiration cases, which occur when the marrow is fibrotic or densely cellular. Overall both the procedures are complementary to each other and must be performed together for better evaluation of bone marrow.
Authors and Affiliations
Akhil Kapoor
Keywords
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