Role of Bone Marrow Derived Autologous Mesenchymal Stem Cells in Fracture Healing in Rabbits
Journal Title: Journal of Bone and Joint Diseases - Year 2017, Vol 0, Issue 0
Abstract
Introduction: In patients with fractures, the bone marrow derived autologous stem cells have a therapeutic potential to accelerate the healing process and treat nonunion. It has become a clinical necessity to develop the novel therapeutic approaches to accelerate fracture healing. In our study we evaluated the effect of bone marrow derived autologous mesenchymal stem cells in fracture healing in rabbits by injecting them locally at the fracture site. Method: For this study we osteotomised the mid shaft of the ulna in 28 rabbits and divided them into two groups. One group was injected with bone marrow derived autologous mesenchymal stem cells at the fracture site, whereas another group was not given any injection and served as control group. Both the groups were assessed radiologically, morphologically, volumetrically and histologically at 4, 8, 12 and 20 weeks. Result: The analysis of the different parameters of our study showed that MSCs injected group showed enhanced fracture healing at 4, 8 and 12 weeks as compared to the control group, however, the results were similar at 20 weeks in both the groups. Conclusion: Hence, it can be concluded that the injection of the bone marrow derived autologous mesenchymal stem cells locally at the fracture site hastens the process of fracture healing in the rabbits at earlier phases.
Authors and Affiliations
Rajeev Kumar, Sandeep Kumar, Daljit Singh, Satish Chandra Goel
Keywords
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