Role of Calretinin in the Pathogenesis of Odontogenic Cysts and Tumors
Journal Title: Scholars Journal of Dental Sciences - Year 2017, Vol 4, Issue 8
Abstract
Calretinin, a calcium-binding protein, is expressed primarily in certain subtypes ofneurons. It has also been shown to be present in mesotheliomas and few other tumors. The aim ofthe study was to determine the expression of calretinin in selected odontogenic cysts and tumors. Immunohistochemically study forcalretinin was performed on 10 odontogenic tumors ameloblastomas (2 solid ameloblastomas and 2 unicysticameloblastomas) and 2 adenomatoidodontogenic tumors, 2 keratocysticodontogenictumours and 2 cystic calcifying ghost cell odontogenic tumors), 4 odontogenic cysts (2 dentigerous cysts and 2 radicular cysts) and 2 dental follicle tissues. The distribution, intensity, pattern and localization of immunoreactive cells were determined by conventional light microscopy. All 4 ameloblastomas and 2 cystic calcifying ghost cell odontogenictumours showed intense immunopositivity with a diffuse distribution pattern. None of the other cysts and tumours showed reactivity with calretinin. Considering that ameloblastomas and cystic calcifying ghost cell odontogenictumours, in contrast to the other studied cysts and tumours were consistently reactive forcalretinin, this protein may have a role in the pathogenesis ofthese tumours. Keywords:Calretinin; Immunohistochemistry; Odontogenictumours; Odontogenic cysts
Authors and Affiliations
Thakre GR, Desai RS, Mamatha GS Reddy, Chaudhari SM
Keywords
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