Role of carica Papaya Leaf Product in Improving the Platelet Count in Patients with Dengue Fever
Journal Title: International Journal Of Research In Medicine - Year 2017, Vol 6, Issue 2
Abstract
BACKGROUND: Dengue is one of the most important arthropod-borne viral infection of humans in terms of both illness and death. Millions of people are vulnerable to dengue(Estimated 50-100 million per year).Dengue is caused by Dengue virus(DENV)1-4 through AedesAegyptimosquitoe as the predominant vector. It is important torecognise and differentiate the clinical signs and symptoms, alterations in the laboratory parameters in Dengue Fever. Decrease in platelet count is an important finding that develops later after the febrile episode. The treatment of Dengue feveris mainly supportive and symptomatic. No specific treatment is available for dengue associated thrombocytopenia. In several Asian countries Carica Papaya has been used extensively for improving platelet count. AIM: To evaluate the effect of carica papaya leaf extract on platelet count in patients of dengue fever with thrombocytopenia. METHODS: 100 cases of confirmed dengue infection were studied. The subjects were randomized in to two groups,control and study group. Cases were followed-up daily for the clinical and laboratory parameters.They were managed according to the standard guidelines. Study group received Carica papaya leaf extract 500mg three times daily for five days and control group received placebo capsules in same frequency. Platelet count of both the groups were monitored daily and compared. RESULTS:The result showed that there was a significant increase (p<0.01) in platelet count in study group as compared to the control group. Thrombocytopenia associated complications were minimal in study group than the control group. Need for platelet transfusion was less in study group than control group. CONCLUSION: The study concluded that use of Carica papaya leaf extract in patients with thrombocytopenia has improved the platelet count significantly and helped in preventing the complications associated with thrombocytopenia.
Authors and Affiliations
V B Adarsh, Kotresh Doddamane, V Deepak Kumar
Keywords
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