Role of Cartridge based nucleic acid amplification test (CBNAAT) in new sputum negative pulmonary tuberculosis
Journal Title: Journal of International Medicine and Dentistry - Year 2018, Vol 5, Issue 1
Abstract
Introduction: Diagnosis of pulmonary tuberculosis in sputum negative patients for acid fast bacilli is challenging till today. It is a fact that 50-60% patients of pulmonary tuberculosis are sputum negative microscopically. Smear microscopy is the easiest, commonest and widely employed tool for confirmatory diagnosis of pulmonary tuberculosis, but it has low sensitivity and specificity. Sputum culture for Mycobacterium tuberculosis bacteria can increase the diagnostic yield by 20-40%, but it takes long duration of 2-8 weeks when solid media are used or 10-14 days when radiometric system in liquid media are used. Delayed diagnosis causes increased rate of disease transmission in the community. The role of newly introduced cartridge based nucleic acid amplification test (CBNAAT) in the revised national TB control program (RNTCP) is highly promising with a higher yield of bacteriological diagnosis in sputum negative pulmonary tuberculosis patients with detection of rifampicin resistance within 2 hours only. Aims and objectives: The current study is to find out efficacy of CBNAAT in diagnosis of new sputum negative pulmonary tuberculosis patients. The detection of rifampicin resistance is also done in those patients. Materials and Methods: Sputum samples of 100 sputum negative pulmonary tuberculosis patients were sent to District CBNAAT center in sterilized falcon tube container. The CBNAAT result were analyzed. Results: Mycobacterium tuberculosis was detected in thirty one patients (31%). Not a single case was detected as resistant to rifampicin. Conclusion: CBNAAT helps in increased case detection rate in lesser time in new sputum negative pulmonary tuberculosis patients. Rifampicin resistance was not detected in any patient.
Authors and Affiliations
Ganesh Chandra Mohapatra, Sumit Bharti, Mohammed Javed Khan, Smrutiranjan Nayak
Keywords
Related Articles
- EP ID EP393263
- DOI 10.18320/JIMD/201805.0139
- Views 100
- Downloads 0
Role of GeneXpert® MTB/RIF assay for early diagnosis of pulmonary tuberculosis in people living with HIV
Introduction: Tuberculosis (TB) is one of the commonest opportunistic infections and the leading cause of death in HIV patients in developing countries. Diagnosing tuberculosis (TB) in people living with HIV/AIDS is chal...
Predictable Planning: Key to a Successful Smile
Our goal in dental rehabilitation for all dental patients is to regain durable esthetics and masticatory function in conjunction and along with maintainable health of the total masticatory system. The demand for aestheti...
Knowledge and awareness of root canal treatment among general public of Arar, Saudi Arabia
Background: Root canal treatment (RCT) is mainstay nowadays to save the precious natural tooth in the oral cavity. The present study was done to assess the knowledge and awareness of the general public regarding the root...
Targeting B-Cell Receptor Signaling – Changing the treatment landscape of B-Cell Lymphoma
Introduced in 1998, the anti-CD20 monoclonal antibody rituximab, with its unique mechanism of action, was the first agent to improve survival in patients with B-cell lymphoma (BCL) treated with chemotherapy. Laboratory i...
Odontogenic fibroma in a six-year old child presenting as trismus
Odontogenic fibroma is a rare tumour of odontogenic mesenchymal origin, which accounts for only 0.1% of all odontogenic tumours and can be seen either in maxilla or mandible. Though it is seen in second and third decade...